The ferritin nanocage is an endogenous protein that exists in almost all mammals. Its hollow
spherical structure that naturally stores iron ions has been diversely exploited by …

Ferritin has been widely recognized as an ideal drug delivery vehicle owing to its unique
cage-like structure. Coupled with intrinsic targeting ability and excellent biosafety, ferritin …

Fibrinolytic enzymes are proteases responsible for cleavage of fibrin mesh in thrombus clots,
which are the primary causative agents in cardiovascular diseases. Developing safe …

Occlusion of blood vessels caused by thrombi is the major pathogenesis of various
catastrophic cardiovascular diseases. Thrombi can be prevented or treated by …

Thrombosis is a global health issue and one of the leading factors of death. However, its
diagnosis has been limited to the late stages, and its therapeutic window is too narrow to …

Ischemic stroke is one of the major causes of severe disability and death worldwide. It is
mainly caused by a sudden reduction in cerebral blood flow due to obstruction of the …

Thrombus formed in blood vessel is a progressive process, which would lead to life-
threatening thrombotic diseases such as ischemic stroke. Unlike other diseases, the …

Nanoparticles (NPs) have been widely used as target delivery vehicles for therapeutic
goods; however, compared with inorganic and organic nanomaterials, protein …

Ferritin is an endogenous protein which is self-assembled by 24 subunits into a highly
uniform nanocage structure. Due to the drug-encapsulating ability in the hollow inner cavity …

Complications with atherosclerosis can often lead to fatal clot formation and blood vessel
occlusion–also known as atherothrombosis. A key component to the development of …