Genetic alterations of TRAF proteins in human cancers

S Zhu, J Jin, S Gokhale, AM Lu, H Shan… - Frontiers in …, 2018 - frontiersin.org
The tumor necrosis factor receptor (TNF-R)-associated factor (TRAF) family of cytoplasmic
adaptor proteins regulate the signal transduction pathways of a variety of receptors …

The relationship between TRAF6 and tumors

J Li, N Liu, L Tang, B Yan, X Chen, J Zhang… - Cancer Cell …, 2020 - Springer
Tumor necrosis factor receptor (TNFR)-related factors (TRAFs) are important linker
molecules in the tumor necrosis factor superfamily (TNFSF) and the Toll-like/interleukin-1 …

TRAF6 regulates the signaling pathway influencing colorectal cancer function through ubiquitination mechanisms

Z Guangwei, C Zhibin, W Qin, L Chunlin… - Cancer …, 2022 - Wiley Online Library
Tumor necrosis factor receptor‐associated factor‐6 (TRAF6) is a ubiquitin E3 ligase. TRAF6
plays an important role in tumor invasion and metastasis. However, the specific mechanism …

CD147 mediates epidermal malignant transformation through the RSK2/AP-1 pathway

X Zhang, Y Guo, T Xiao, J Li, A Guo, L Lei, C Jin… - Journal of Experimental …, 2022 - Springer
Background Malignant transformation of the epidermis is an essential process in the
pathogenesis of cutaneous squamous-cell carcinoma (cSCC). Although evidence has …

TRAF6 promotes the progression and growth of colorectal cancer through nuclear shuttle regulation NF-kB/c-jun signaling pathway

G Zhu, Z Cheng, Y Huang, W Zheng, S Yang, C Lin… - Life sciences, 2019 - Elsevier
Aims TRAF6 is an intracellular signal adapter molecule plays a significant role in tumor
development. However, the specific mechanism causes and promotes of colorectal cancer …

SNHG16/miR‐605‐3p/TRAF6/NF‐κB feedback loop regulates hepatocellular carcinoma metastasis

YL Hu, Y Feng, YY Chen, JZ Liu, Y Su… - Journal of cellular …, 2020 - Wiley Online Library
The mechanism by which miR‐605‐3p regulates hepatocellular carcinoma (HCC)
metastasis has not been clarified. In this study, we found that miR‐605‐3p was down …

The immunohistochemical assessment of neoangiogenesis factors in squamous cell carcinomas and their precursors in the skin

C Daneluzzi, SM Seyed Jafari, R Hunger… - Journal of clinical …, 2022 - mdpi.com
Cutaneous squamous cell carcinoma (cSCC) is a common skin cancer. Well-limited forms
can be easily treated with excision, but locally advanced cancers can, unfortunately …

Targeted therapy for cisplatin‐resistant lung cancer via aptamer‐guided nano‐zinc carriers containing USP14 siRNA

X Zhao, X Wu, H Wang, S Lai, J Wang - MedComm, 2023 - Wiley Online Library
Cisplatin (DDP) is a common therapeutic option for non‐small cell lung carcinoma (NSCLC).
However, some patients fail to respond to the DDP chemotherapy. Therefore, identifying …

[HTML][HTML] TRAF6 activates fibroblasts to cancer-associated fibroblasts through FGF19 in tumor microenvironment to benefit the malignant phenotype of melanoma cells

Y Guo, X Zhang, W Zeng, J Zhang, L Cai, Z Wu… - Journal of Investigative …, 2020 - Elsevier
Cancer-associated fibroblasts (CAFs) are an important component of the tumor
microenvironment and mediate tumor progression in various cancers. A previous study …

TRAF6 promotes chemoresistance to paclitaxel of triple negative breast cancer via regulating PKM2‐mediated glycolysis

H Xu, L Li, B Dong, J Lu, K Zhou, X Yin… - Cancer Medicine, 2023 - Wiley Online Library
Ample evidence reveals that glycolysis is crucial to tumor progression; however, the
underlying mechanism of its drug resistance is still worth being further explored. TRAF6, an …