Molecular mechanisms of environmental exposures and human disease
A substantial proportion of disease risk for common complex disorders is attributable to
environmental exposures and pollutants. An appreciation of how environmental pollutants …
environmental exposures and pollutants. An appreciation of how environmental pollutants …
Metals and molecular carcinogenesis
Y Zhu, M Costa - Carcinogenesis, 2020 - academic.oup.com
Many metals are essential for living organisms, but at higher doses they may be toxic and
carcinogenic. Metal exposure occurs mainly in occupational settings and environmental …
carcinogenic. Metal exposure occurs mainly in occupational settings and environmental …
Review of arsenic toxicity, speciation and polyadenylation of canonical histones
M Costa - Toxicology and applied pharmacology, 2019 - Elsevier
Arsenic contamination impacts hundreds of millions of people in the world. Arsenic is a well-
established human carcinogen and has been shown to cause skin, lung, bladder, liver …
established human carcinogen and has been shown to cause skin, lung, bladder, liver …
Arsenic-induced epigenetic changes in cancer development
WN Saintilnord, Y Fondufe-Mittendorf - Seminars in cancer biology, 2021 - Elsevier
Arsenic is a ubiquitous metalloid whose high levels of toxicity pose major health concerns to
millions of people worldwide by increasing susceptibility to various cancers and non-cancer …
millions of people worldwide by increasing susceptibility to various cancers and non-cancer …
Mechanisms of nickel carcinogenesis
Nickel (Ni) is a naturally occurring metal that is widely used in an array of industries such as
nickel plating, refinery, welding, as well as in the manufacturing of stainless steel, jewelry …
nickel plating, refinery, welding, as well as in the manufacturing of stainless steel, jewelry …
Influence of arsenic on global levels of histone posttranslational modifications: a review of the literature and challenges in the field
CG Howe, MV Gamble - Current environmental health reports, 2016 - Springer
Arsenic is a human carcinogen and also increases the risk for non-cancer outcomes.
Arsenic-induced epigenetic dysregulation may contribute to arsenic toxicity. Although there …
Arsenic-induced epigenetic dysregulation may contribute to arsenic toxicity. Although there …
The role of Mediator and Little Elongation Complex in transcription termination
Mediator is a coregulatory complex that regulates transcription of Pol II-dependent genes.
Previously, we showed that human Mediator subunit MED26 plays a role in the recruitment …
Previously, we showed that human Mediator subunit MED26 plays a role in the recruitment …
Secretory expression fine-tuning and directed evolution of diacetylchitobiose deacetylase by Bacillus subtilis
Z Jiang, T Niu, X Lv, Y Liu, J Li, W Lu… - Applied and …, 2019 - Am Soc Microbiol
Diacetylchitobiose deacetylase has great application potential in the production of chitosan
oligosaccharides and monosaccharides. This work aimed to achieve high-level secretory …
oligosaccharides and monosaccharides. This work aimed to achieve high-level secretory …
Developmental exposure to 50 parts-per-billion arsenic influences histone modifications and associated epigenetic machinery in a region-and sex-specific manner in …
CR Tyler, AK Hafez, ER Solomon, AM Allan - Toxicology and applied …, 2015 - Elsevier
Epidemiological studies report that arsenic exposure via drinking water adversely impacts
cognitive development in children and, in adults, can lead to greater psychiatric disease …
cognitive development in children and, in adults, can lead to greater psychiatric disease …
Dysregulation of DNA methylation induced by past arsenic treatment causes persistent genomic instability in mammalian cells
M Mauro, F Caradonna, CB Klein - … and molecular mutagenesis, 2016 - Wiley Online Library
The mechanisms by which arsenic‐induced genomic instability is initiated and maintained
are poorly understood. To investigate potential epigenetic mechanisms, in this study we …
are poorly understood. To investigate potential epigenetic mechanisms, in this study we …