Over the past several decades, the treatment of rheumatoid arthritis (RA) has advanced
significantly, and clinical, structural, and functional remission are achievable therapeutic …

Purpose of Review A subset of patients with rheumatoid arthritis (RA) who fail multiple
biologic therapies are deemed to have “difficult-to-treat”(D2T) RA. In 2021, a European …

Rheumatoid arthritis (RA) is an autoimmune disease causing severe symptoms that are
difficult to treat. Nano-drug delivery system is recognized as a promising strategy for …

Current clinical therapeutic efficacy for the treatment of osteo‐and rheumatoid‐arthritis is
obviously limited. Although mesenchymal stem cells (MSCs) are considered as a source of …

Objective To investigate the prevalence of poly-refractory rheumatoid arthritis (RA) defined
as failure of all biological (b)/targeted synthetic (ts)-disease-modifying drugs (DMARDs). To …

Spondyloarthritis (SpA) is a polymorphic rheumatic musculoskeletal disease (RMD), with
different phenotypic presentations, namely axial (ax-SpA)(radiographic or non-radiographic) …

Objectives Most studies on difficult-to-treat rheumatoid arthritis (D2T RA) have focused on
established RA. Here, we analyse whether disease activity in the early stages of RA could …

Objectives To compare the features of difficult-to-treat rheumatoid arthritis (D2TRA) patients
using two different definitions according to the previous failure of targeted therapies …

Psoriatic arthritis (PsA) is a complex and chronic inflammatory condition in which the
achievement of the best possible disease control has been proposed as the treatment target …

Ревматоидный артрит (РА)-наиболее частое иммуновоспалительное (аутоиммунное)
ревматическое заболевание (ИВРЗ), проявляющийся хроническим эрозивным …