Uncontrolled haemorrhage is a major preventable cause of death in patients with traumatic
injury. Trauma-induced coagulopathy (TIC) describes abnormal coagulation processes that …

Objectives We review the evidence for tranexamic acid (TXA) for the treatment and
prevention of bleeding caused by surgery, trauma and bleeding disorders. We highlight …

Background Whether prehospital administration of tranexamic acid increases the likelihood
of survival with a favorable functional outcome among patients with major trauma and …

Background Major haemorrhage is a clinical emergency that results in morbidity and
mortality: practice guidance is important to reduce these risks. Delayed recognition of …

Importance Whole-blood (WB) resuscitation has gained renewed interest among civilian
trauma centers. However, there remains insufficient evidence that WB as an adjunct to …

METHODS We performed a single-center, prospective, cluster randomized, prehospital
through in-hospital whole blood pilot trial for injured air medical patients. We compared …

Tranexamic acid (TXA) is a potent antifibrinolytic with documented efficacy in reducing blood
loss and allogeneic red blood cell transfusion in several clinical settings. With a growing …

Importance Tranexamic acid is widely available and used off-label in patients with bleeding
traumatic injury, although the literature does not consistently agree on its efficacy and safety …

Tranexamic acid (TXA) is a widely used antifibrinolytic agent that has been used since the
1960's to reduce blood loss in various conditions. TXA is a lysine analogue that competes …

BACKGROUND Hemorrhage is the leading cause of preventable death after injury. Others
have shown that delays in massive transfusion cooler arrival increase mortality, while …