Oxycodone, a semisynthetic derivative of naturally occurring thebaine, an opioid alkaloid,
has been available for more than 100 years. Although thebaine cannot be used …

The majority of women undergoing cesarean delivery in the United States receive neuraxial
morphine, the most effective form of postoperative analgesia for this surgery. Current …

A wide range of organic and inorganic brominated compounds including molecular bromine
have been extensively used as oxidants in many organic photo-redox transformations in …

Postoperative analgesia in patients undergoing spinal fusion surgery is challenging due to
the invasiveness of the surgical procedure and the frequent use of opioids preoperatively by …

The objective of study was to investigate the inhibitory effect of sinomenine on neuropathic
pain on dorsal root ganglia (DRG). The DRG cell line and spinal nerve ligation (SNL) model …

Modified-release opioid tablets were introduced into surgical practice in the belief that they
provided superior pain relief and reduced nursing workload, and they rapidly became …

Background There is limited data on enhanced recovery after surgery (ERAS) protocols after
ventral hernia repair (VHR). This study reports the impact of multimodal analgesia on opioid …

Prescription opioid abuse during and after pregnancy is a rising public health concern.
While earlier studies have documented that offspring exposed to opioids in utero have …

After surgery, over 80% of people experience moderate-to-severe acute pain. Poorly
controlled postoperative pain limits recovery and is associated with detrimental short-and …

Opioids are powerful analgesic drugs that are used clinically to treat pain. However, chronic
opioid use causes compensatory neuroadaptations that result in greater pain sensitivity …