Endothelial cells (ECs) lining all blood vessels are subjected to large mechanical stresses
that regulate their structure and function in health and disease. Here, we review EC …

The use of nanoparticles (NPs) in nanomedicine holds great promise for the treatment of
diseases for which conventional therapies present serious limitations. Additionally, NPs can …

The ion channels Piezo1 and TRPV4 have both, independently, been implicated in high
venous pressure–and fluid shear stress–induced vascular hyperpermeability in endothelial …

Organs-on-a-chip, or OoCs, are microfluidic tissue culture devices with micro-scaled
architectures that repeatedly achieve biomimicry of biological phenomena. They are well …

In many medical disciplines, red blood cells are discovered to be biomarkers since they
“experience” various conditions in basically all organs of the body. Classical examples are …

Background and Objectives Ras–mitogen-activated protein kinase (MAPK) signaling
abnormalities occur in most brain arteriovenous malformations (bAVMs). No means exist to …

Endothelial cells (ECs) that reside on the surface of blood vessels are constantly exposed to
mechanical stimulation, including shear stress. Fluid shear stress (FSS) controls multiple …

Shear stress is essential for normal physiology and malignancy. Common physiological
processes–such as blood flow, particle flow in the gut, or contact between migratory cell …

Endothelial mechanobiology is a key consideration in the progression of vascular
dysfunction, including atherosclerosis. However mechanistic connections between the …

Vessel remodeling is essential for a functional and mature vascular network. According to
the difference in endothelial cell (EC) behavior, we classified vessel remodeling into vessel …