Epilepsy is a prevalent neurological disorder characterized by unprovoked seizures. γ-
Aminobutyric acid (GABA) serves as the primary fast inhibitory neurotransmitter in the brain …

Cortical GABAergic interneurons are critical components of neural networks. They provide
local and long-range inhibition and help coordinate network activities involved in various …

Phenobarbital (PB) remains the first-line medication for neonatal seizures. Yet, seizures in
many newborns, particularly those associated with perinatal ischemia, are resistant to PB …

Rett syndrome is a neurodevelopmental disorder caused by loss-of-function mutations in the
methyl-CpG binding protein-2 (MeCP2) gene that is characterized by epilepsy, intellectual …

Developmental neurogenesis is a tightly regulated spatiotemporal process with its
dysregulation implicated in neurodevelopmental disorders. NMDA receptors are glutamate …

The cation-chloride cotransporters KCC2 and NKCC1 regulate the intracellular Cl−
concentration and cell volume of neurons and/or glia. The Cl− extruder KCC2 is expressed …

Introduction γ-Aminobutyric acid (GABA) type A receptors (GABAARs) are ligand-gated Cl-
channels that mediate the bulk of inhibitory neurotransmission in the mature CNS and are …

Developmental neurogenesis is a tightly regulated spatiotemporal process with its
dysfunction implicated in neurodevelopmental disorders. NMDA receptors are glutamate …

The endocannabinoid system (ECS) is a widespread neuromodulatory system that is
present from early stages of prenatal development and plays a critical role in central nervous …