[HTML][HTML] Antimicrobial peptides: an update on classifications and databases

A Bin Hafeez, X Jiang, PJ Bergen, Y Zhu - International journal of …, 2021 - mdpi.com
Antimicrobial peptides (AMPs) are distributed across all kingdoms of life and are an
indispensable component of host defenses. They consist of predominantly short cationic …

Staphylococcus aureus and atopic dermatitis: a complex and evolving relationship

JA Geoghegan, AD Irvine, TJ Foster - Trends in microbiology, 2018 - cell.com
Staphylococcus aureus is frequently isolated from the skin of atopic dermatitis (AD) patients
during flares. The normal microbiota is disrupted and the diversity of the microorganisms on …

[HTML][HTML] Therapeutic potential of bacteriophage endolysins for infections caused by Gram-positive bacteria

H Liu, Z Hu, M Li, Y Yang, S Lu, X Rao - Journal of biomedical science, 2023 - Springer
Abstract Gram-positive (G+) bacterial infection is a great burden to both healthcare and
community medical resources. As a result of the increasing prevalence of multidrug-resistant …

Alternatives to antibiotics—a pipeline portfolio review

L Czaplewski, R Bax, M Clokie, M Dawson… - The Lancet infectious …, 2016 - thelancet.com
Antibiotics have saved countless lives and enabled the development of modern medicine
over the past 70 years. However, it is clear that the success of antibiotics might only have …

[HTML][HTML] The global threat of antimicrobial resistance: science for intervention

I Roca, M Akova, F Baquero, J Carlet, M Cavaleri… - New microbes and new …, 2015 - Elsevier
In the last decade we have witnessed a dramatic increase in the proportion and absolute
number of bacterial pathogens resistant to multiple antibacterial agents. Multidrug-resistant …

[HTML][HTML] Phage-encoded endolysins

F Abdelrahman, M Easwaran, OI Daramola, S Ragab… - Antibiotics, 2021 - mdpi.com
Due to the global emergence of antibiotic resistance, there has been an increase in
research surrounding endolysins as an alternative therapeutic. Endolysins are phage …

[HTML][HTML] Non-traditional antibacterial therapeutic options and challenges

U Theuretzbacher, LJV Piddock - Cell host & microbe, 2019 - cell.com
The global challenges presented by drug-resistant bacterial infections have stimulated much
activity in finding new treatments. This review summarizes the progress and setbacks of non …

Engineered endolysin-based “Artilysins” to combat multidrug-resistant gram-negative pathogens

Y Briers, M Walmagh, V Van Puyenbroeck… - MBio, 2014 - Am Soc Microbiol
The global threat to public health posed by emerging multidrug-resistant bacteria in the past
few years necessitates the development of novel approaches to combat bacterial infections …

[HTML][HTML] Recent advances in bacteriophage-based therapeutics: Insight into the post-antibiotic era

H Ling, X Lou, Q Luo, Z He, M Sun, J Sun - Acta Pharmaceutica Sinica B, 2022 - Elsevier
Antibiotic resistance is one of the biggest threats to global health, as it can make the
treatment of bacterial infections in humans difficult owing to their high incidence rate …

[HTML][HTML] Enzymes and mechanisms employed by tailed bacteriophages to breach the bacterial cell barriers

S Fernandes, C São-José - Viruses, 2018 - mdpi.com
Monoderm bacteria possess a cell envelope made of a cytoplasmic membrane and a cell
wall, whereas diderm bacteria have and extra lipid layer, the outer membrane, covering the …