Sensorineural hearing loss (SNHL) is the most common sensory disorder. Its underlying
etiologies include a broad spectrum of genetic and environmental factors that can lead to …

Impairments of vision and hearing are highly prevalent conditions limiting the quality of life
and presenting a major socioeconomic burden. For a long time, retinal and cochlear …

Following destruction of sensory cells of the organ of Corti, spiral ganglion cells (SGC) in the
guinea pig degenerate. Chronic electrical stimulation via cochlear prostheses can enhance …

Cochlear gene transfer studies in animal models have utilized mainly two delivery methods:
direct injection through the round window membrane (RWM) or intracochlear infusion …

Murine models are ideal for studying cochlear gene transfer, as many hearing loss-related
mutations have been discovered and mapped within the mouse genome. However, because …

Cochlear gene transfer is a promising new approach for inner ear therapy. Previous studies
have demonstrated hair cell protection with cochlear gene transfer not only in the inoculated …

Aminoglycosides are commonly used antimicrobial drugs that often have ototoxic side
effects. The ototoxicity often involves permanent loss of cochlear hair cells (HCs) …

Successful delivery of genes to the inner ear has been demonstrated using a variety of
vectors and animal models. As our understanding of the molecular pathophysiology of …

To utilize the rapidly accumulating genetic information for developing new therapeutic
technologies for inner ear disease, it is necessary to design technologies for expressing …

Two possible approaches for cochlear gene transfer have been inoculation via the round
window membrane and through a cochleostomy. The aim of this study was to determine …