Microglia/macrophages (MMΦ) are highly plastic phagocytes that can promote both injury
and repair in diseased brain through the distinct function of classically activated and …

Background and Purpose—Intracerebral hemorrhage (ICH) remains a major medical
problem for which there is no effective treatment. Oxidative and cytotoxic damage plays an …

Nrf2 is a key transcriptional factor for antioxidant response element (ARE)-regulated genes.
While its beneficial role has been described for stroke, its contribution to intracerebral …

Background and Purpose—Intracerebral hemorrhage (ICH) represents a devastating form of
stroke for which there is no effective treatment. This preclinical study was designed to …

C-reactive protein (CRP) is an important mediator and a hallmark of the acute-phase
response to inflammation. High-sensitivity assays that accurately measure levels of CRP …

Intracerebral hemorrhage (ICH) is a subtype of stroke involving formation of hematoma
within brain parenchyma, which accounts for 8–15% of all strokes in Western societies and …

After intracerebral hemorrhage (ICH), the brain parenchyma is exposed to blood containing
red blood cells (RBCs) and consequently to its lysis products. Iron-rich hemoglobin (Hb) is …

Intracerebral hemorrhage (ICH) is a major health concern, with high rates of mortality and
morbidity and no highly effective clinical interventions. Basic research in animal models of …

Sepsis is not only a significant cause of mortality worldwide but has particularly devastating
effects on the central nervous system of survivors. It is therefore crucial to understand the …

No effective therapy is available for treating intracerebral hemorrhage (ICH). One of several
key components of brain damage after ICH is the neurotoxicity of blood products. Within …