[HTML][HTML] Pathophysiology of coagulation and emerging roles for extracellular vesicles in coagulation cascades and disorders

H Al-Koussa, I AlZaim, ME El-Sabban - Journal of Clinical Medicine, 2022 - mdpi.com
The notion of blood coagulation dates back to the ancient Greek civilization. However, the
emergence of innovative scientific discoveries that started in the seventeenth century …

Antiplatelet drugs: potential therapeutic options for the management of neurodegenerative diseases

SK Beura, R Dhapola, AR Panigrahi… - Medicinal Research …, 2023 - Wiley Online Library
The blood platelet plays an important role but often remains under‐recognized in several
vascular complications and associated diseases. Surprisingly, platelet hyperactivity and …

[HTML][HTML] Thromboinflammatory processes at the nexus of metabolic dysfunction and prostate cancer: The emerging role of periprostatic adipose tissue

I AlZaim, A Al-Saidi, SH Hammoud, N Darwiche… - Cancers, 2022 - mdpi.com
Simple Summary As overweight and obesity increase among the population worldwide, a
parallel increase in the number of individuals diagnosed with prostate cancer was observed …

Interruption of perivascular and perirenal adipose tissue thromboinflammation rescues prediabetic cardioautonomic and renovascular deterioration

A Al-Saidi, IF Alzaim, SH Hammoud, G Al Arab… - Clinical …, 2024 - portlandpress.com
The cardiovascular and renovascular complications of metabolic deterioration are
associated with localized adipose tissue dysfunction. We have previously demonstrated that …

Periprostatic adipose tissue thromboinflammation triggers prostatic neoplasia in early metabolic impairment: Interruption by rivaroxaban

I AlZaim, N El-Nikhely, A Al-Saidi, N Mougharbil… - Life Sciences, 2023 - Elsevier
Aims Prostate cancer is among the highest incidence malignancies in men with a
prevalence rate increasing in parallel to the rising global trends in metabolic disorders …

[HTML][HTML] Deciphering the irregular risk of stroke increased by obesity classes: a stratified mendelian randomization study

X Zou, L Wang, L Xiao, Z Xu, T Yao, M Shen… - Frontiers in …, 2021 - frontiersin.org
Background To investigate the relationship between different classes of obesity and stroke,
we conducted a stratified Mendelian randomization (MR) study. Methods The body mass …

The serum metabolomic profiles of atrial fibrillation patients treated with direct oral anticoagulants or vitamin K antagonists

A Vignoli, AM Gori, M Berteotti, F Cesari, B Giusti… - Life Sciences, 2024 - Elsevier
Aims Long-term oral anticoagulation is the primary therapy for preventing ischemic stroke in
patients with atrial fibrillation (AF). Different types of oral anticoagulant drugs can have …

[HTML][HTML] Study on the antithrombotic effect and physiological mechanism of okanin

Y Liu, B Xiong, X Qiu, H Hao, A Sha - Biomedicine & Pharmacotherapy, 2022 - Elsevier
The objectives of this study were to investigate the antithrombotic effect and physiological
mechanism of okanin, a flavonoid monomer in Coreopsis tinctoria Nutt. The antithrombotic …

Relationship of Warfarin and Apixaban with Vascular Function in Patients with Atrial Fibrillation.

RT Junejo, D Gupta, RL Snowdon, GYH Lip… - Journal of vascular …, 2024 - karger.com
Introduction: Atrial fibrillation (AF) is associated with endothelial damage/dysfunction.
Herein, we tested the hypothesis that brachial artery flow-mediated dilation (FMD) is …

Association between 23 drugs and Parkinson's disease: A two‐sample Mendelian randomization study

Z Xie, H Zhou, Z Qiu, Z Fan, W Yang, J Zhang… - Brain and …, 2023 - Wiley Online Library
Background Parkinson's disease (PD) is a common degenerative nervous system disease.
At present, there are certain limitations in various treatment options aimed at preventing or …