Protein 3-nitrotyrosine is a posttranslational modification found in many pathological
conditions from acute to chronic diseases. Could 3-nitrotyrosine formation participate on the …

Protein tyrosine nitration (PTN) is a post-translational modification occurring under the action
of a nitrating agent. Tyrosine is modified in the 3-position of the phenolic ring through the …

Inevitable byproducts of aerobic metabolism are free radicals and other highly reactive
oxidants and nitrosants that are continuously formed within cells. Most cells generally …

Peroxynitrite anion (ONOO−) is a reactive species of increasingly recognized biological
relevance that contributes to oxidative tissue damage. At present, however, there is limited …

The nitration of free tyrosine or protein tyrosine residues generates 3-nitrotyrosine the
detection of which has been utilised as a footprint for the in vivo formation of peroxynitrite …

Revised and updated, Chemical Reagents for Protein Modification, Third Edition is an
encyclopedic work describing the many approaches to the site-specific modification of …

There is growing evidence that cardiovascular disease is associated with progressive
changes in the production of free radicals and radical-derived reactive species. These …

Alzheimer's (AD) and Parkinson's diseases (PD) are late-onset neurodegenerative diseases
that have tremendous impact on the lives of affected individuals, their families, and society …

Peroxynitrite (ONOO−) is a potent oxidizing and nitrating agent produced by the reaction of
nitric oxide with superoxide. It readily nitrates phenolic compounds such as tyrosine …

Several pathologies of the cardiovascular system are associated with an augmented
production of nitric oxide and/or superoxide-derived oxidants and/or alteration in the …