Vascular tone critically depends on the endothelial release of nitric oxide and prostacyclin.
Superoxide anions counteract these relaxations by trapping nitric oxide under formation of …

Nitric oxide participates in a wide array of physiological processes, ranging from
neurotransmission to precursor of cytotoxic effector molecules of the immune system …

Superoxide dismutase (SOD) catalyzes the nitration of specific tyrosine residues in proteins
by peroxynitrite (ONOO−), which may be the damaging gain‐of‐function resulting from …

Of the three mammalian members belonging to the sarco (endo) plasmic reticulum Ca2+
ATPase (SERCA) family, SERCA2 is evolutionary the oldest and shows the most wide tissue …

NO2Tyr (3-Nitrotyrosine) is a modified amino acid that is formed by nitric oxide-derived
species and has been implicated in the pathology of diverse human diseases. Nitration of …

Eosinophil peroxidase (EPO) has been implicated in promoting oxidative tissue injury in
conditions ranging from asthma and other allergic inflammatory disorders to cancer and …

Parkinson's disease is a neurodegenerative disorder of unknown pathogenesis. Oxidative
stress has been proposed as one of several pathogenic hypotheses. Evidence for the …

In laboratory rodents, caloric restriction (CR) retards several age‐dependent physiological
and biochemical changes in skeletal muscle, including increased steady‐state levels of …

Oxidative stress mediated by nitric oxide (NO) and its toxic metabolite peroxynitrite has
previously been associated with motor neuron degeneration in amyotrophic lateral sclerosis …

Oxidative post-translational modification of proteins by molecular oxygen (O2)-and nitric
oxide (• NO)-derived reactive species is a usual process that occurs in mammalian tissues …