Although a multisystem disease, systemic sclerosis (SSc) most commonly affects the skin.
The skin lesion is characterized by progressive changes, chief amongst which are vascular …

The immunohistochemical detection of nitrotyrosine is a robust method for detecting
peroxynitrite and other reactive nitrogen species. Success depends on optimizing conditions …

Nitrotyrosine is widely recognized as a surrogate marker of up-regulated inducible NO
synthase expression at sites of inflammation. However, the potential immunogenicity of …

Neurons must remove aggregated, damaged proteins in order to survive. Among the ways of
facilitating this protein quality control is the ubiquitin-proteasomal system (UPS) …

BACKGROUND The risk for prostate cancer seems to be reduced by certain antioxidant
compounds (vitamins E and A, and selenium). METHODS Antioxidant enzymes and …

Apoptosis of endothelial cells related to homocysteine (Hcy) has been reported in several
studies. In this study, we evaluated whether reactive oxygen species (ROS)-producing …

Elevated levels of protein tyrosine nitration have been found in various neurodegenerative
diseases and age-related pathologies. Until recently, however, the lack of an efficient …

Peroxynitrite (PN) is likely to be generated in vivo from nitric oxide and superoxide. We have
previously shown that prostacyclin synthase, a heme‐thiolate enzyme essential for …

The addition of peroxynitrite to purified cytochrome P450 2B1 resulted in a concentration-
dependent loss of the NADPH-and reductase-supported or tert-butylhydroperoxide …

To understand the mechanism leading to autoantibody production, it is of importance to
reveal how self-components that are otherwise inactive as antigens acquire immunogenicity …