Nitric oxide-derived reactive species have been implicated in many disorders. Protein
nitrotyrosine is often used as a stable marker of these reactive species. Using …

We have identified a denitrase activity in macrophages that is upregulated following
macrophage activation, which is shown by mass spectrometry to recognize nitrotyrosines in …

The peptide ligase subtiligase, derived from subtilisin, has been employed in the
identification of protein N-termini in complex mixtures. Here, the peptide ester substrates for …

Considerable evidence both in vitro and in vivo implicates protein damage by peroxynitrite
as a probable mechanism of cell death. Herein, we report that treatment of bovine brain …

Much of the damaging action of nitric oxide in heart may be due to its diffusion-limited
reaction with superoxide to form peroxynitrite. Direct infusion of peroxynitrite into isolated …

A substantial body of evidence suggests that nitrative injury contributes to
neurodegeneration in Alzheimer's disease (AD) and other neurodegenerative disorders …

A functional role for stimulated nitric oxide (NO) production was tested in the TCR-triggered
death of mature T lymphocytes. In purified peripheral human T cell blasts or the 2B4 murine …

Putative 'protein nitratases', which catalyze denitration of peroxynitrite (PN)-treated proteins,
were detected in the homogenate/crude extract of rat brains and hearts. Nitratase activity …

Peroxynitrite, a potent oxidant generated in inflammatory tissues, can nitrate tyrosine
residues on a variety of proteins. Based on previous studies suggesting that actin might be a …

Tryptophan hydroxylase, the initial and rate-limiting enzyme in serotonin biosynthesis, is
inactivated by peroxynitrite in a concentration-dependent manner. This effect is prevented by …