The initial step in estrogen-regulated transcription is the binding of a ligand to its cognate
receptors, named estrogen receptors (ERα and ERβ). Phytochemicals present in foods and …

Apigenin (APG), a natural flavonoid compound with anti-inflammatory and antioxidative
properties, was found to promote in vitro osteogenic differentiation and to accelerate in vivo …

The repair of bone defects resulting from high-energy trauma, infection, or pathological
fracture remains a challenge in the field of medicine. The development of biomaterials …

Background It is well-established that osteoclast activity is significantly influenced by
fluctuations in intracellular pH. Consequently, a pH-sensitive gated nano-drug delivery …

Preclinical rodent models are used to examine the relationship between tea consumption
and bone health, where tea is available for rodents and typically replaced weekly. However …

Natural products exhibit various biological activities that play essential roles in human health
and disease treatment. However, during the quality control of natural products …

Objective Osteoporosis is a common clinical bone disease that occurs most frequently in
middle-aged and elderly people. Various traditional herbal medicine formulations have …

Polymer-based composites are considered promising candidates for bone repair as they
possess some outstanding advantages over ceramic/metallic/polymeric biomaterials …

There is an increasing demand for innovative strategies that effectively promote
osteogenesis and enhance bone regeneration. The critical process of bone regeneration …

Age-associated osteosarcopenia is an unresolved syndrome characterized by the
concomitant loss of bone (osteopenia) and skeletal muscle (sarcopenia) tissues increasing …