Targeted treatment for bacterial infections: prospects for pathogen-specific antibiotics coupled with rapid diagnostics
T Maxson, DA Mitchell - Tetrahedron, 2016 - Elsevier
The advent of antibiotics in the early twentieth century catalyzed a medical revolution,
drastically reducing mortality due to bacterial infections. Along with numerous other …
drastically reducing mortality due to bacterial infections. Along with numerous other …
Immune therapy in sepsis: Are we ready to try again?
Immune therapy to ease the burden of sepsis has thus far failed to consistently improve
patient outcomes. Advances in cancer immune therapy and awareness that prolonged …
patient outcomes. Advances in cancer immune therapy and awareness that prolonged …
Microphysiological systems: next generation systems for assessing toxicity and therapeutic effects of nanomaterials
Microphysiological systems, also known as organ‐on‐a‐chip platforms, show promise for
the development of new testing methods that can be more accurate than both conventional …
the development of new testing methods that can be more accurate than both conventional …
Biomimetic nanomaterial strategies for virus targeting: Antiviral therapies and vaccines
JA Jackman, BK Yoon, L Ouyang… - Advanced Functional …, 2021 - Wiley Online Library
The ongoing coronavirus disease 2019 (COVID‐19) pandemic highlights the importance of
developing effective virus targeting strategies to treat and prevent viral infections. Since virus …
developing effective virus targeting strategies to treat and prevent viral infections. Since virus …
In vitro immune organs-on-chip for drug development: a review
The current drug development practice lacks reliable and sensitive techniques to evaluate
the immunotoxicity of drug candidates, ie, their effect on the human immune system. This, in …
the immunotoxicity of drug candidates, ie, their effect on the human immune system. This, in …
Point of care technologies for sepsis diagnosis and treatment
Sepsis is a rapidly progressing, life threatening immune response triggered by infection that
affects millions worldwide each year. Current clinical diagnosis relies on broad physiological …
affects millions worldwide each year. Current clinical diagnosis relies on broad physiological …
High resolution and rapid separation of bacteria from blood using elasto‐inertial microfluidics
S Narayana Iyengar, T Kumar, G Mårtensson… - …, 2021 - Wiley Online Library
Improved sample preparation has the potential to address unmet needs for fast turnaround
sepsis tests. In this work, we report elasto‐inertial based rapid bacteria separation from …
sepsis tests. In this work, we report elasto‐inertial based rapid bacteria separation from …
Sepsis: frontiers in supportive care, organisation and research
Because of its high incidence and clinical complexity, sepsis is a major challenge to
clinicians and researchers and a global burden to healthcare systems and society. Despite …
clinicians and researchers and a global burden to healthcare systems and society. Despite …
Spatial control of probiotic bacteria in the gastrointestinal tract assisted by magnetic particles
MT Buss, P Ramesh, MA English… - Advanced …, 2021 - Wiley Online Library
Engineered probiotics have the potential to diagnose and treat a variety of gastrointestinal
(GI) diseases. However, these exogenous bacterial agents have limited ability to effectively …
(GI) diseases. However, these exogenous bacterial agents have limited ability to effectively …
Broad-Spectrum Clearance of Lipopolysaccharides from Blood Based on a Hemocompatible Dihistidine Polymer
J Chen, Z Shi, X Yang, X Zhang, D Wang… - … Applied Materials & …, 2023 - ACS Publications
Blood infection can release toxic bacterial lipopolysaccharides (LPSs) into bloodstream,
trigger a series of inflammatory reactions, and eventually lead to multiple organ dysfunction …
trigger a series of inflammatory reactions, and eventually lead to multiple organ dysfunction …