Targeted treatment for bacterial infections: prospects for pathogen-specific antibiotics coupled with rapid diagnostics

T Maxson, DA Mitchell - Tetrahedron, 2016 - Elsevier
The advent of antibiotics in the early twentieth century catalyzed a medical revolution,
drastically reducing mortality due to bacterial infections. Along with numerous other …

Immune therapy in sepsis: Are we ready to try again?

R Davies, K O'Dea, A Gordon - Journal of the Intensive Care …, 2018 - journals.sagepub.com
Immune therapy to ease the burden of sepsis has thus far failed to consistently improve
patient outcomes. Advances in cancer immune therapy and awareness that prolonged …

Microphysiological systems: next generation systems for assessing toxicity and therapeutic effects of nanomaterials

N Ashammakhi, MA Darabi, B Çelebi‐Saltik… - Small …, 2020 - Wiley Online Library
Microphysiological systems, also known as organ‐on‐a‐chip platforms, show promise for
the development of new testing methods that can be more accurate than both conventional …

Biomimetic nanomaterial strategies for virus targeting: Antiviral therapies and vaccines

JA Jackman, BK Yoon, L Ouyang… - Advanced Functional …, 2021 - Wiley Online Library
The ongoing coronavirus disease 2019 (COVID‐19) pandemic highlights the importance of
developing effective virus targeting strategies to treat and prevent viral infections. Since virus …

In vitro immune organs-on-chip for drug development: a review

A Shanti, J Teo, C Stefanini - Pharmaceutics, 2018 - mdpi.com
The current drug development practice lacks reliable and sensitive techniques to evaluate
the immunotoxicity of drug candidates, ie, their effect on the human immune system. This, in …

Point of care technologies for sepsis diagnosis and treatment

T Oeschger, D McCloskey, V Kopparthy, A Singh… - Lab on a Chip, 2019 - pubs.rsc.org
Sepsis is a rapidly progressing, life threatening immune response triggered by infection that
affects millions worldwide each year. Current clinical diagnosis relies on broad physiological …

High resolution and rapid separation of bacteria from blood using elasto‐inertial microfluidics

S Narayana Iyengar, T Kumar, G Mårtensson… - …, 2021 - Wiley Online Library
Improved sample preparation has the potential to address unmet needs for fast turnaround
sepsis tests. In this work, we report elasto‐inertial based rapid bacteria separation from …

Sepsis: frontiers in supportive care, organisation and research

A Perner, A Rhodes, B Venkatesh, DC Angus… - Intensive care …, 2017 - Springer
Because of its high incidence and clinical complexity, sepsis is a major challenge to
clinicians and researchers and a global burden to healthcare systems and society. Despite …

Spatial control of probiotic bacteria in the gastrointestinal tract assisted by magnetic particles

MT Buss, P Ramesh, MA English… - Advanced …, 2021 - Wiley Online Library
Engineered probiotics have the potential to diagnose and treat a variety of gastrointestinal
(GI) diseases. However, these exogenous bacterial agents have limited ability to effectively …

Broad-Spectrum Clearance of Lipopolysaccharides from Blood Based on a Hemocompatible Dihistidine Polymer

J Chen, Z Shi, X Yang, X Zhang, D Wang… - … Applied Materials & …, 2023 - ACS Publications
Blood infection can release toxic bacterial lipopolysaccharides (LPSs) into bloodstream,
trigger a series of inflammatory reactions, and eventually lead to multiple organ dysfunction …