Neurotoxicity evoked by organophosphates and available countermeasures

L Pulkrabkova, B Svobodova, J Konecny… - Archives of …, 2023 - Springer
Organophosphorus compounds (OP) are a constant problem, both in the military and in the
civilian field, not only in the form of acute poisoning but also for their long-lasting …

Treatment of cholinergic‐induced status epilepticus with polytherapy targeting GABA and glutamate receptors

J Niquet, D Nguyen, M de Araujo Furtado… - Epilepsia …, 2023 - Wiley Online Library
Despite new antiseizure medications, the development of cholinergic‐induced refractory
status epilepticus (RSE) continues to be a therapeutic challenge as pharmacoresistance to …

Part per trillion level DMMP gas sensor based on calixarene modified organic thin film transistor

J Song, T Guo, C Huang, M Liu, H Cui, W Huang… - Chemical Engineering …, 2022 - Elsevier
Dimethyl methylphosphonate (DMMP) is a simulant of nerve agent sarin, which still remains
a great challenge to detect due to lack of sensitive, selective and stable sensor. In this work …

Efficacy of a combined anti-seizure treatment against cholinergic established status epilepticus following a sarin nerve agent insult in rats

S Lazar, A Neufeld-Cohen, I Egoz, S Baranes… - Toxicology and Applied …, 2024 - Elsevier
The development of refractory status epilepticus (SE) following sarin intoxication presents a
therapeutic challenge. Here, we evaluated the efficacy of delayed combined double or triple …

A delayed treatment model for the evaluation of scopolamine for VX nerve agent intoxication

AS Cornelissen, EE Garcia, RE Raulli, J Laney… - Toxicology and Applied …, 2021 - Elsevier
Most research on medical countermeasures for nerve agent exposure assumes a military
scenario, in which (autoinjector) treatment is envisaged to be available immediately. In a …