Normal aortic valves are composed of valve endothelial cells (VECs) and valve interstitial
cells (VICs). VICs are the major cell population and have distinct embryonic origins in the …

Background Ectopic vascular calcification is a common condition associated with aging,
atherosclerosis, diabetes, and/or chronic kidney disease. Smooth muscle cells are the best …

Bicuspid aortic valve is the most prevalent cardiac valvular malformation. It is associated
with a high rate of long‐term morbidity including development of calcific aortic valve disease …

Traditionally, the development of diabetic complications has been attributed to the
biochemical pathways driving hyperglycaemic cell damage, while reparatory mechanisms …

Vascular calcification (VC) is a frequent complication of chronic kidney disease (CKD) and is
a predictor of cardiovascular morbidity and mortality. In the present study, we investigated …

Systemic vascular impairment is the most common complication of diabetes. Advanced
glycation end products (AGEs) can exacerbate diabetes‐related vascular damage by …

Histologic evaluations revealed excessive accumulations of macrophages and absence of
fibroblastic interstitial cells in explanted bioprosthetic valves. Comprehensive gene and …

The presence of cardiovascular calcification significantly predicts patients' morbidity and
mortality. Calcific mineral deposition within the soft cardiovascular tissues disrupts the …

Calcific aortic valve disease (CAVD) affects 25% of people over 65, and the late-stage
stenotic state can only be treated with total valve replacement, requiring 85,000 surgeries …

Objectives Bicuspid aortic valve (BAV) is associated with increased risk of valvular
degeneration and ascending aortic aneurysm formation and rupture. We sought to evaluate …