Immune-mediated inflammatory diseases (IMIDs) are characterized by excessive and
uncontrolled inflammation and thrombosis, both of which are responsible for organ damage …

The humoral immune response provides specific, long-lived protection against invading
pathogens, via immunoglobulin production and other memory functions. IgG, the most …

Secondary hypogammaglobulinemia (SHG) is characterized by reduced immunoglobulin
levels due to acquired causes of decreased antibody production or increased antibody loss …

There is a significant geographical imbalance in global supply of plasma with 65% collected
in the United States. This results in a dependency of other countries on United States supply …

The neonatal fragment crystallizable (Fc) receptor (FcRn) functions as a recycling
mechanism to prevent degradation and extend the half-life of IgG and albumin in the …

Antibodies can initiate lung injury in a variety of disease states such as autoimmunity,
transfusion reactions, or after organ transplantation, but the key factors determining in vivo …

Immunoglobulin G (IgG) antibodies are major drivers of inflammation during infectious and
autoimmune diseases. In pooled serum IgG (IVIg), however, antibodies have a potent …

Sepsis and autoimmune diseases remain major causes of morbidity and mortality. The last
decade has seen a new appreciation of platelets in host defense, in both immunity and …

Objective To analyze the effectiveness and safety of intravenous immunoglobulin (IVIG)
given in routine care to patients with systemic sclerosis (SSc). Methods A retrospective …

Antibody-based therapeutics are now standard in the treatment of neuroinflammatory
diseases, and the spectrum of neurological diseases targeted by those approaches …