The majority of antivirals available target viral proteins; however, RNA is emerging as a new
and promising antiviral target due to the presence of highly structured RNA in viral genomes …

RNA has diverse cellular functionality, including regulating gene expression, protein
translation, and cellular response to stimuli, due to its intricate structures. Over the past …

Chemical modulation of proteins enables a mechanistic understanding of biology and
represents the foundation of most therapeutics. However, despite decades of research, 80 …

In response to the urgent need for potent severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) therapeutics, this study introduces an innovative nucleoside tailoring strategy …

Early lung cancer screening by computed tomography is hampered by pulmonary nodules
caused by massive COVID‐19 infections, necessitating an ultrasensitive approach for the …

RNA targeting, specifically with small molecules, is a relatively new and rapidly emerging
avenue with the promise to expand the target space in the drug discovery field. From being …

The androgen receptor (AR) is a ligand-dependent nuclear transcription factor belonging to
the steroid hormone nuclear receptor family. Due to its roles in regulating cell proliferation …

Thermally activated delayed fluorescence (TADF) material has attracted great attention as a
promising metal-free organic light-emitting diode material with a high theoretical efficiency …

Ribonucleases (RNases) cleave and process RNAs, thereby regulating the biogenesis,
metabolism, and degradation of coding and noncoding RNAs. Thus, small molecules …

Conditionally replicating viruses (CRVs) are a type of virus with one or more essential gene
functions that are impaired resulting in the disruption of viral genome replication, protein …