The male reproductive system consists of testes, a series of ducts connecting the testes to
the external urethral orifice, accessory sex glands, and the penis. Spermatogonial stem cells …

Background Conflicting results regarding alterations to sperm DNA methylation in cases of
spermatogenesis defects, male infertility and poor developmental outcomes have been …

Background Spermatozoa have a remarkable epigenome in line with their degree of
specialization, their unique nature and different requirements for successful fertilization …

Differentiation potency of human dental pulp cells (hDPCs) is essential for dentin
regeneration. DNA methylation is one of the major epigenetic mechanisms and is suggested …

Epigenetic modifications, including DNA methylation and histone modifications, determine
the way DNA is packaged within the nucleus and regulate cell-specific gene expression …

DNA 甲基转移酶是参与表观遗传修饰的重要蛋白家族. 哺乳动物DNA 甲基转移酶主要包括
DNMT1, DNMT2, DNMT3A, DNMT3B 和DNMT3L, 其中, DNMT1, DNMT3A 和DNMT3B …

For a better understanding of epigenetic regulation of cell differentiation, it is important to
analyze DNA methylation at a specific site. In this study, we examined changes in the …

In vertebrates, DNA methyltransferase 3 (Dnmt3) homologues are responsible for de novo
DNA methylation and play important roles in germ cell development. In the present study …

ABSTRACT Decitabine (5-aza-2ʹdeoxycytidine; DAC) is a DNA methyltransferase inhibitor
used to hypomethylate the epigenome. Current dosing regimens of DAC for use in mice vary …

Mammalian spermatogenesis is characterized by disproportionate germ cell apoptosis. The
high frequency of apoptosis is considered a safety mechanism that serves to avoid …