Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive lung disease characterized by
progressive lung scarring and the histological picture of usual interstitial pneumonia (UIP). It …

Usual interstitial pneumonia (UIP) is characterised by a distinctive morphological and
radiological appearance that was considered the pathognomonic hallmark of idiopathic …

Pulmonary fibrosis (PF) is a form of chronic lung disease characterized by pathologic
epithelial remodeling and accumulation of extracellular matrix (ECM). To comprehensively …

Rationale: The contributions of diverse cell populations in the human lung to pulmonary
fibrosis pathogenesis are poorly understood. Single-cell RNA sequencing can reveal …

Idiopathic pulmonary fibrosis (IPF) is a fatal disease characterized by interstitial remodelling,
leading to compromised lung function. Cellular senescence markers are detectable within …

The lung is an architecturally complex organ comprising a heterogeneous mixture of various
epithelial and mesenchymal lineages. We use single-cell RNA sequencing and signaling …

Collagen-producing cells maintain the complex architecture of the lung and drive pathologic
scarring in pulmonary fibrosis. Here we perform single-cell RNA-sequencing to identify all …

The pathogenesis of idiopathic pulmonary fibrosis (IPF), an intractable interstitial lung
disease, is unclear. Recessive mutations in some genes implicated in Hermansky-Pudlak …

Patients with estrogen receptor (ER)-positive breast cancer are at risk of metastatic relapse
for decades after primary tumor resection and treatment, a consequence of dormant …

Thyroid hormone (TH) is critical for the maintenance of cellular homeostasis during stress
responses, but its role in lung fibrosis is unknown. Here we found that the activity and …