CD38 mediates lung fibrosis by promoting alveolar epithelial cell aging
Rationale: A prevailing paradigm recognizes idiopathic pulmonary fibrosis (IPF) originating
from various alveolar epithelial cell (AEC) injuries, and there is a growing appreciation of …
from various alveolar epithelial cell (AEC) injuries, and there is a growing appreciation of …
Targeting hypoxia-inducible factor-1α/pyruvate dehydrogenase kinase 1 axis by dichloroacetate suppresses bleomycin-induced pulmonary fibrosis
Hypoxia has long been implicated in the pathogenesis of fibrotic diseases. Aberrantly
activated myofibroblasts are the primary pathological driver of fibrotic progression, yet how …
activated myofibroblasts are the primary pathological driver of fibrotic progression, yet how …
Vitamin D metabolism is dysregulated in asthma and chronic obstructive pulmonary disease
DA Jolliffe, C Stefanidis, Z Wang… - American journal of …, 2020 - atsjournals.org
Rationale: Vitamin D deficiency is common in patients with asthma and chronic obstructive
pulmonary disease (COPD). Low 25-hydroxyvitamin D (25 [OH] D) levels may represent a …
pulmonary disease (COPD). Low 25-hydroxyvitamin D (25 [OH] D) levels may represent a …
[HTML][HTML] Transcriptional regulatory model of fibrosis progression in the human lung
To develop a systems biology model of fibrosis progression within the human lung we
performed RNA sequencing and microRNA analysis on 95 samples obtained from 10 …
performed RNA sequencing and microRNA analysis on 95 samples obtained from 10 …
Reducing protein oxidation reverses lung fibrosis
Idiopathic pulmonary fibrosis is characterized by excessive deposition of collagen in the
lung, leading to chronically impaired gas exchange and death,–. Oxidative stress is believed …
lung, leading to chronically impaired gas exchange and death,–. Oxidative stress is believed …
Epigenetic Regulation of Profibrotic Macrophages in Systemic Sclerosis–Associated Interstitial Lung Disease
A Papazoglou, M Huang, M Bulik… - Arthritis & …, 2022 - Wiley Online Library
Objective Systemic sclerosis–associated interstitial lung disease (SSc‐ILD) is the leading
cause of death in patients with SSc with unclear pathogenesis and limited treatment options …
cause of death in patients with SSc with unclear pathogenesis and limited treatment options …
[HTML][HTML] Identification of a missense variant in SPDL1 associated with idiopathic pulmonary fibrosis
Idiopathic pulmonary fibrosis (IPF) is a fatal disorder characterised by progressive,
destructive lung scarring. Despite substantial progress, the genetic determinants of this …
destructive lung scarring. Despite substantial progress, the genetic determinants of this …
Classification of usual interstitial pneumonia in patients with interstitial lung disease: assessment of a machine learning approach using high-dimensional …
Background Idiopathic pulmonary fibrosis is a progressive fibrotic lung disease that distorts
pulmonary architecture, leading to hypoxia, respiratory failure, and death. Diagnosis is …
pulmonary architecture, leading to hypoxia, respiratory failure, and death. Diagnosis is …
[HTML][HTML] COVID-19 lung disease shares driver AT2 cytopathic features with Idiopathic pulmonary fibrosis
S Sinha, V Castillo, CR Espinoza, C Tindle… - …, 2022 - thelancet.com
Background In the aftermath of Covid-19, some patients develop a fibrotic lung disease, ie,
post-COVID-19 lung disease (PCLD), for which we currently lack insights into pathogenesis …
post-COVID-19 lung disease (PCLD), for which we currently lack insights into pathogenesis …
The diagnosis of idiopathic pulmonary fibrosis: current and future approaches
FJ Martinez, A Chisholm, HR Collard… - The Lancet …, 2017 - thelancet.com
With the recent development of two effective treatments for patients with idiopathic
pulmonary fibrosis, an accurate diagnosis is crucial. The traditional approach to diagnosis …
pulmonary fibrosis, an accurate diagnosis is crucial. The traditional approach to diagnosis …