Idiopathic pulmonary fibrosis (IPF) is a chronic progressive interstitial lung disease
characterized by patchy scarring of the distal lung with limited therapeutic options and poor …

Rationale: Usual interstitial pneumonia (UIP) is the histopathologic hallmark of idiopathic
pulmonary fibrosis. Although UIP can be detected by high-resolution computed tomography …

Background Of late, high-throughput microarray and sequencing data have been
extensively used to monitor biomarkers and biological processes related to many diseases …

Wnt/β-catenin signaling regulates progenitor cell fate decisions during lung development
and in various adult tissues. Ectopic activation of Wnt/β-catenin signaling promotes tissue …

Aberrant fibroblast function plays a key role in the pathogenesis of idiopathic pulmonary
fibrosis, a devastating disease of unrelenting extracellular matrix deposition in response to …

Rationale: Increased abundance and stiffness of the extracellular matrix, in particular
collagens, is a hallmark of idiopathic pulmonary fibrosis (IPF). FK506-binding protein 10 …

Pulmonary inflammatory responses lie under circadian control; however, the importance of
circadian mechanisms in the underlying fibrotic phenotype is not understood. Here, we …

Multiple distinct cell types of the human lung and airways have been defined by single cell
RNA sequencing (scRNAseq). Here we present a multi-omics spatial lung atlas to define …

In the progression phase of idiopathic pulmonary fibrosis (IPF), the normal alveolar structure
of the lung is lost and replaced by remodeled fibrotic tissue and by bronchiolized cystic …

Pathogenic fibrotic diseases, including Idiopathic Pulmonary Fibrosis (IPF), have some of
the worst prognoses and affect millions of people worldwide. With unclear etiology and …