Conditional deletion of Nedd4-2 in lung epithelial cells causes progressive pulmonary fibrosis in adult mice
J Duerr, DHW Leitz, M Szczygiel, D Dvornikov… - Nature …, 2020 - nature.com
Idiopathic pulmonary fibrosis (IPF) is a chronic progressive interstitial lung disease
characterized by patchy scarring of the distal lung with limited therapeutic options and poor …
characterized by patchy scarring of the distal lung with limited therapeutic options and poor …
Usual interstitial pneumonia can be detected in transbronchial biopsies using machine learning
DG Pankratz, Y Choi, U Imtiaz… - Annals of the …, 2017 - atsjournals.org
Rationale: Usual interstitial pneumonia (UIP) is the histopathologic hallmark of idiopathic
pulmonary fibrosis. Although UIP can be detected by high-resolution computed tomography …
pulmonary fibrosis. Although UIP can be detected by high-resolution computed tomography …
Meta-analytic support vector machine for integrating multiple omics data
SH Kim, JH Jhong, JJ Lee, JY Koo - BioData mining, 2017 - Springer
Background Of late, high-throughput microarray and sequencing data have been
extensively used to monitor biomarkers and biological processes related to many diseases …
extensively used to monitor biomarkers and biological processes related to many diseases …
Wnt/β-catenin signaling is critical for regenerative potential of distal lung epithelial progenitor cells in homeostasis and emphysema
Wnt/β-catenin signaling regulates progenitor cell fate decisions during lung development
and in various adult tissues. Ectopic activation of Wnt/β-catenin signaling promotes tissue …
and in various adult tissues. Ectopic activation of Wnt/β-catenin signaling promotes tissue …
[HTML][HTML] Functional Pdgfra fibroblast heterogeneity in normal and fibrotic mouse lung
CS Trempus, BN Papas, MI Sifre, CD Bortner… - JCI insight, 2023 - ncbi.nlm.nih.gov
Aberrant fibroblast function plays a key role in the pathogenesis of idiopathic pulmonary
fibrosis, a devastating disease of unrelenting extracellular matrix deposition in response to …
fibrosis, a devastating disease of unrelenting extracellular matrix deposition in response to …
FK506-binding protein 10, a potential novel drug target for idiopathic pulmonary fibrosis
CA Staab-Weijnitz, IE Fernandez… - American journal of …, 2015 - atsjournals.org
Rationale: Increased abundance and stiffness of the extracellular matrix, in particular
collagens, is a hallmark of idiopathic pulmonary fibrosis (IPF). FK506-binding protein 10 …
collagens, is a hallmark of idiopathic pulmonary fibrosis (IPF). FK506-binding protein 10 …
The circadian clock protein REVERBα inhibits pulmonary fibrosis development
PS Cunningham, P Meijer… - Proceedings of the …, 2020 - National Acad Sciences
Pulmonary inflammatory responses lie under circadian control; however, the importance of
circadian mechanisms in the underlying fibrotic phenotype is not understood. Here, we …
circadian mechanisms in the underlying fibrotic phenotype is not understood. Here, we …
A spatial multi-omics atlas of the human lung reveals a novel immune cell survival niche
E Madissoon, AJ Oliver, V Kleshchevnikov… - Biorxiv, 2021 - biorxiv.org
Multiple distinct cell types of the human lung and airways have been defined by single cell
RNA sequencing (scRNAseq). Here we present a multi-omics spatial lung atlas to define …
RNA sequencing (scRNAseq). Here we present a multi-omics spatial lung atlas to define …
[HTML][HTML] NF-κB drives epithelial-mesenchymal mechanisms of lung fibrosis in a translational lung cell model
P Sieber, A Schäfer, R Lieberherr, SL Caimi, U Lüthi… - JCI insight, 2023 - ncbi.nlm.nih.gov
In the progression phase of idiopathic pulmonary fibrosis (IPF), the normal alveolar structure
of the lung is lost and replaced by remodeled fibrotic tissue and by bronchiolized cystic …
of the lung is lost and replaced by remodeled fibrotic tissue and by bronchiolized cystic …
[HTML][HTML] IPF pathogenesis is dependent upon TGFβ induction of IGF-1
DM Hernandez, JH Kang, M Choudhury… - … : official publication of …, 2020 - ncbi.nlm.nih.gov
Pathogenic fibrotic diseases, including Idiopathic Pulmonary Fibrosis (IPF), have some of
the worst prognoses and affect millions of people worldwide. With unclear etiology and …
the worst prognoses and affect millions of people worldwide. With unclear etiology and …