Among the four G protein–coupled receptors (H1–H4) identified as mediators of the biologic
effects of histamine, the H3 receptor (H3R) is distinguished for its almost exclusive …

The human neurotensin 1 receptor (hNTS1) is a G protein-coupled receptor involved in
many physiological functions, including analgesia, hypothermia, and hypotension. To gain a …

The histamine H4 receptor (H4R) activates Gαi-mediated signaling and recruits β-arrestin2
upon stimulation with histamine. β-Arrestins play a regulatory role in G protein-coupled …

The histamine H 3 receptor (H 3 R) is a neurotransmitter receptor that is primarily found in
the brain, where it controls the release and synthesis of histamine, as well as the release of …

Radioligands used previously for histamine H3 receptor (H3R) are accompanied by a
number of disadvantages. In this study, we report the synthesis of the new H3R radioligand …

Summary Background DISC 1 (Disrupted‐In‐Schizophrenia‐1) is considered a genetic risk
factor for schizophrenia (SZ) and bipolar disorder (BD). DISC 1 regulates microtubule …

We have reported that prenatal alcohol exposure (PAE) elevates histamine H 3 receptor
(H3R) agonist-mediated inhibition of glutamatergic neurotransmission in the dentate gyrus …

Uterine relaxation is crucial during preterm labor. Phosphodiesterase-4 (PDE-4) inhibitors
have been proposed as tocolytics. Some thalidomide analogs are PDE-4 inhibitors. The aim …

Abstract Rationale Histamine H 3 receptors (H 3 Rs) are co-expressed with dopamine D 1
receptors (D 1 Rs) by striato-nigral medium spiny GABAergic neurons, where they …

Recently, multi‐target directed ligands have been of research interest for multifactorial
disorders such as Alzheimer's disease (AD). Since H3 receptors (H3Rs) and …