Hippo pathway was initially identified through genetic screens for genes regulating organ
size in fruitflies. Recent studies have highlighted the role of Hippo signaling as a key …

Simple Summary In this review, we aim to summarize the current clinical and biological
knowledge for patients affected by a rare soft-tissue sarcoma, the CIC-rearranged sarcoma …

Summary Spinocerebellar ataxia type 1 (SCA1) is a paradigmatic neurodegenerative
disease in that it is caused by a mutation in a broadly expressed protein, ATXN1; however …

Summary EGFR-RAS-ERK signaling promotes growth and proliferation in many cell types,
and genetic hyperactivation of RAS-ERK signaling drives many cancers. Yet, despite …

Background The T cell-inflamed tumor microenvironment, characterized by CD8 T cells and
type I/II interferon transcripts, is an important cancer immunotherapy biomarker. Tumor …

Transcription factor fusions (TFFs) are present in∼ 30% of soft-tissue sarcomas. TFFs are
not readily “druggable” in a direct pharmacologic manner and thus have proven difficult to …

Capicua (CIC) is an important downstream molecule of RTK/RAS/MAPK pathway. The
regulatory mechanism of CIC underlying tumorigenesis in oligodendroglioma, where CIC is …

Capicua (CIC) is an evolutionarily conserved transcription factor. CIC contains a high-
mobility group (HMG) box that recognizes specific DNA sequences to regulate the …

Embryonic stem cells (ESCs) can be maintained in the naïve state through inhibition of
Mek1/2 and Gsk3 (2i). A relevant effect of 2i is the inhibition of Cdk8/19, which are negative …

Central tolerance is achieved through positive and negative selection of thymocytes
mediated by T cell receptor (TCR) signaling strength. Thus, dysregulation of the thymic …