Background Depression is a common source of human disability for which etiologic insights
remain limited. Although abnormalities of monoamine neurotransmission, including …

Impulse control disorders (ICDs) in Parkinson's disease (PD) have a high cumulative
incidence and negatively impact quality of life. ICDs are influenced by a complex interaction …

Cumulative studies indicated that adult hippocampal neurogenesis might be involved in the
action mechanism of antidepressant drugs and/or the pathophysiology of depression …

Abstract Allopregnanolone (3α-hydroxy-5α-pregnan-20-one) is a major cholesterol-derived
neurosteroid in the central nervous system and is synthesized from progesterone by …

Antiretroviral therapy (ART) has transformed HIV into a chronic condition, lengthening and
improving the lives of individuals living with this virus. Despite successful suppression of HIV …

The success of anti-retroviral therapy has improved the quality of life and lifespan of HIV+
individuals, transforming HIV infection into a chronic condition. These improvements have …

In the present work, we studied the effects of piplartine (PIP), an amide alkaloid isolated from
the roots of Piper tuberculatum (Piperaceae), in the elevated plus maze, open field, rota rod …

The majority of neuronal proteins involved in cellular signaling undergo different
posttranslational modifications significantly affecting their functions. One of these …

Background Perivascular macrophages and microglia are critical to CNS function. Drugs of
abuse increase extracellular dopamine in the CNS, exposing these cells to elevated levels …

We review the conflicting results from imaging studies of dopamine transporter availability in
depressed patients and also discuss the heterogeneity of the variables involved. Major …