Accurately predicting the binding affinity between proteins and ligands is crucial in drug
screening and optimization, but it is still a challenge in computer-aided drug design. The …

DNA carries the genetic information required for the synthesis of RNA and proteins and
plays an important role in many processes of biological development. Understanding the …

Abstract The family of Janus Kinases (JAKs) associated with the JAK–signal transducers
and activators of transcription signaling pathway plays a vital role in the regulation of various …

Understanding crucial factors that affect the binding affinity of protein-RNA complexes is vital
for comprehending their recognition mechanisms. This study involved compiling …

This study examines the remarkable effectiveness of Withaferin-A (WA), a withanolide
obtained from Withania somnifera (Ashwagandha), in encountering the mortiferous breast …

Nucleic acids do not fold into a single conformation, and dynamic ensembles are needed to
describe their propensities to cycle between different conformations when performing …

Mitochondrial genomes of land plants are large and exhibit a complex mode of gene
organization and expression, particularly at the post-transcriptional level. The primary …

In the past few years, the number of RNA-binding proteins (RBP) and RNA-RBP interactions
has increased significantly. Here, we review recent developments in the methodology for …

Biological processes such as transcription, repair, and regulation require interactions
between DNA and proteins. To unravel their functions, it is imperative to determine the high …

The correct functioning of organisms heavily relies on proteins and RNAs, which hold
significant roles in governing biological pathways and mechanisms from a molecular …