Among the complications of diabetes, cardiovascular events and cardiac insufficiency are
considered two of the most important causes of death. Experimental and clinical evidence …

Metformin is a biguanide drug widely used as the initial treatment of type 2 diabetes. Despite
its widespread use, its precise mechanisms of action remain incompletely characterised. Its …

The present study aimed to investigate whether dexmedetomidine (Dex) exerts
cardioprotection effect through inhibiting ferroptosis. Myocardial ischemia/reperfusion injury …

Amyloid β-protein (Aβ) is reported to activate NLRP3 inflammasomes and drive pyroptosis,
which is subsequently involved in the pathogenesis of neurodegenerative diseases, such as …

Ischemia‐reperfusion injury (IRI) refers to a syndrome in which tissue damage is further
aggravated and organ function further deteriorates when blood flow is restored after a period …

Biofilm‐infected diabetic wounds (BIDWs) with hyperglycemia and bacterial colonization are
characterized by disordered inflammation and abnormal activation of NLRP3 …

Ischemia–reperfusion (I/R) injury is a disease process that affects several vital organs. There
is widespread agreement that the NLRP3 inflammasome pathway plays a crucial role in the …

NOD‐like receptor family, pyrin domain‐containing protein 3 (NLRP3) inflammasome‐
mediated pyroptosis is a crucial event in the preeclamptic pathogenesis, tightly linked with …

Metformin, a well‐known AMPK agonist, has been widely used as the first‐line drug for
treating type 2 diabetes. There had been a significant concern regarding the use of …

Retinal ischemia/reperfusion (I/R) injury is a common pathological process responsible for
cellular damage in glaucoma, diabetic retinopathy and hypertensive retinopathy. Metformin …