The immune system comprises diverse specialized cell types that cooperate to defend the
host against a wide range of pathogenic threats. Recent advancements in single-cell and …

Healthy functioning of the female reproductive tract (FRT) depends on balanced and
dynamic regulation by hormones during the menstrual cycle, pregnancy and childbirth. The …

The uterus has critical biomechanical functions in pregnancy and undergoes dramatic
material growth and remodeling from implantation to parturition. The intrinsic material …

The endometrial lining of the uterus is essential for women's reproductive health and
consists of several different types of epithelial and stromal cells. Although models such as …

Research focused on human reproductive biology has primarily relied upon clinical samples
affording mainly descriptive studies with limited implementation of functional or mechanistic …

Cells do not live in a vacuum, but in a milieu defined by cell–cell communication that can be
measured via emerging high-resolution spatial transcriptomics approaches. However …

The intestinal immune system is highly adapted to maintaining tolerance to the commensal
microbiota and self-antigens while defending against invading pathogens,. Recognizing …

Abstract Motivation Gene regulatory networks (GRNs) in a cell provide the tight feedback
needed to synchronize cell actions. However, genes in a cell also take input from, and …

Human germline–soma segregation occurs during weeks 2–3 in gastrulating embryos.
Although direct studies are hindered, here, we investigate the dynamics of human primordial …

The uterus-lining endometrium is essential to mammalian reproduction, receiving and
accommodating the embryo for proper development. Despite its key role, mechanisms …