Nanodrug delivery: is the enhanced permeability and retention effect sufficient for curing cancer?

Y Nakamura, A Mochida, PL Choyke… - Bioconjugate …, 2016 - ACS Publications
Nanotechnology offers several attractive design features that have prompted its exploration
for cancer diagnosis and treatment. Nanosized drugs have a large loading capacity, the …

[HTML][HTML] Surface functionalization and targeting strategies of liposomes in solid tumor therapy: A review

MK Riaz, MA Riaz, X Zhang, C Lin, KH Wong… - International journal of …, 2018 - mdpi.com
Surface functionalization of liposomes can play a key role in overcoming the current
limitations of nanocarriers to treat solid tumors, ie, biological barriers and physiological …

Liposomes as nanomedical devices

G Bozzuto, A Molinari - International journal of nanomedicine, 2015 - Taylor & Francis
Since their discovery in the 1960s, liposomes have been studied in depth, and they continue
to constitute a field of intense research. Liposomes are valued for their biological and …

Iron oxide based nanoparticles for multimodal imaging and magnetoresponsive therapy

N Lee, D Yoo, D Ling, MH Cho, T Hyeon… - Chemical …, 2015 - ACS Publications
Magnetic nanoparticles have received tremendous attention in diverse fields because of
their unique nanoscale physicochemical properties and the potential for a wide range of …

Stimuli‐responsive liposomes for drug delivery

Y Lee, DH Thompson - Wiley Interdisciplinary Reviews …, 2017 - Wiley Online Library
The ultimate goal of drug delivery is to increase the bioavailability and reduce the toxic side
effects of the active pharmaceutical ingredient (API) by releasing them at a specific site of …

[HTML][HTML] Liposomes for tumor targeted therapy: a review

S Wang, Y Chen, J Guo, Q Huang - International Journal of Molecular …, 2023 - mdpi.com
Liposomes, the most widely studied nano-drug carriers in drug delivery, are sphere-shaped
vesicles consisting of one or more phospholipid bilayers. Compared with traditional drug …

[HTML][HTML] Improving conventional enhanced permeability and retention (EPR) effects; what is the appropriate target?

H Kobayashi, R Watanabe, PL Choyke - Theranostics, 2014 - ncbi.nlm.nih.gov
Nano-sized therapeutic agents have several advantages over low molecular weight agents
such as a larger loading capacity, the ability to protect the payload until delivery, more …

Novel methods for liposome preparation

YP Patil, S Jadhav - Chemistry and physics of lipids, 2014 - Elsevier
Liposomes are bilayer vesicles which have found use, among other applications, as drug
delivery vehicles. Conventional techniques for liposome preparation and size reduction …

Liposomes as carriers of hydrophilic small molecule drugs: strategies to enhance encapsulation and delivery

JO Eloy, MC de Souza, R Petrilli, JPA Barcellos… - Colloids and surfaces B …, 2014 - Elsevier
Although hydrophilic small molecule drugs are widely used in the clinic, their rapid
clearance, suboptimal biodistribution, low intracellular absorption and toxicity can limit their …

[HTML][HTML] Nanomedicine therapeutic approaches to overcome cancer drug resistance

JL Markman, A Rekechenetskiy, E Holler… - Advanced drug delivery …, 2013 - Elsevier
Nanomedicine is an emerging form of therapy that focuses on alternative drug delivery and
improvement of the treatment efficacy while reducing detrimental side effects to normal …