Parental advisory: maternal and paternal stress can impact offspring neurodevelopment
Parental stress exposures are implicated in the risk for offspring neurodevelopmental and
neuropsychiatric disorders, prompting critical examination of preconception and prenatal …
neuropsychiatric disorders, prompting critical examination of preconception and prenatal …
Transgenerational epigenetic influences of paternal environmental exposures on brain function and predisposition to psychiatric disorders
S Yeshurun, AJ Hannan - Molecular Psychiatry, 2019 - nature.com
In recent years, striking new evidence has demonstrated non-genetic inheritance of
acquired traits associated with parental environmental exposures. In particular, this …
acquired traits associated with parental environmental exposures. In particular, this …
Reproductive tract extracellular vesicles are sufficient to transmit intergenerational stress and program neurodevelopment
Extracellular vesicles (EVs) are a unique mode of intercellular communication capable of
incredible specificity in transmitting signals involved in cellular function, including germ cell …
incredible specificity in transmitting signals involved in cellular function, including germ cell …
Astroglial correlates of neuropsychiatric disease: From astrocytopathy to astrogliosis
Complex roles for astrocytes in health and disease continue to emerge, highlighting this
class of cells as integral to function and dysfunction of the nervous system. In particular …
class of cells as integral to function and dysfunction of the nervous system. In particular …
d-Amino acids: new clinical pathways for brain diseases
IN de Oliveira Souza, R Roychaudhuri… - Trends in Molecular …, 2023 - cell.com
Free d-amino acids (d-AAs) are emerging as a novel and important class of signaling
molecules in many organs, including the brain and endocrine systems. There has been …
molecules in many organs, including the brain and endocrine systems. There has been …
Multigenerational and transgenerational effects of paternal exposure to drugs of abuse on behavioral and neural function
LR Goldberg, TJ Gould - European Journal of Neuroscience, 2019 - Wiley Online Library
Addictions are highly heritable disorders, with heritability estimates ranging from 39% to
72%. Multiple studies suggest a link between paternal drug abuse and addiction in their …
72%. Multiple studies suggest a link between paternal drug abuse and addiction in their …
Environmental, genetic and epigenetic contributions to cocaine addiction
RC Pierce, B Fant, SE Swinford-Jackson… - …, 2018 - nature.com
Decades of research on cocaine has produced volumes of data that have answered many
important questions about the nature of this highly addictive drug. Sadly, none of this …
important questions about the nature of this highly addictive drug. Sadly, none of this …
[HTML][HTML] Multigenerational epigenetic inheritance: One step forward, two generations back
JJ Tuscher, JJ Day - Neurobiology of Disease, 2019 - Elsevier
Modifications to DNA and histone proteins serve a critical regulatory role in the developing
and adult brain, and over a decade of research has established the importance of these …
and adult brain, and over a decade of research has established the importance of these …
Ejaculate-mediated paternal effects: evidence, mechanisms and evolutionary implications
Despite serving the primary objective of ensuring that at least one sperm cell reaches and
fertilises an ovum, the male ejaculate (ie spermatozoa and seminal fluid) is a …
fertilises an ovum, the male ejaculate (ie spermatozoa and seminal fluid) is a …
Sperm RNA payload: implications for intergenerational epigenetic inheritance
There is mounting evidence that ancestral life experiences and environment can influence
phenotypes in descendants. The parental environment regulates offspring phenotypes …
phenotypes in descendants. The parental environment regulates offspring phenotypes …