Parental advisory: maternal and paternal stress can impact offspring neurodevelopment

JC Chan, BM Nugent, TL Bale - Biological psychiatry, 2018 - Elsevier
Parental stress exposures are implicated in the risk for offspring neurodevelopmental and
neuropsychiatric disorders, prompting critical examination of preconception and prenatal …

Transgenerational epigenetic influences of paternal environmental exposures on brain function and predisposition to psychiatric disorders

S Yeshurun, AJ Hannan - Molecular Psychiatry, 2019 - nature.com
In recent years, striking new evidence has demonstrated non-genetic inheritance of
acquired traits associated with parental environmental exposures. In particular, this …

Reproductive tract extracellular vesicles are sufficient to transmit intergenerational stress and program neurodevelopment

JC Chan, CP Morgan, N Adrian Leu, A Shetty… - Nature …, 2020 - nature.com
Extracellular vesicles (EVs) are a unique mode of intercellular communication capable of
incredible specificity in transmitting signals involved in cellular function, including germ cell …

Astroglial correlates of neuropsychiatric disease: From astrocytopathy to astrogliosis

R Kim, KL Healey, MT Sepulveda-Orengo… - Progress in Neuro …, 2018 - Elsevier
Complex roles for astrocytes in health and disease continue to emerge, highlighting this
class of cells as integral to function and dysfunction of the nervous system. In particular …

d-Amino acids: new clinical pathways for brain diseases

IN de Oliveira Souza, R Roychaudhuri… - Trends in Molecular …, 2023 - cell.com
Free d-amino acids (d-AAs) are emerging as a novel and important class of signaling
molecules in many organs, including the brain and endocrine systems. There has been …

Multigenerational and transgenerational effects of paternal exposure to drugs of abuse on behavioral and neural function

LR Goldberg, TJ Gould - European Journal of Neuroscience, 2019 - Wiley Online Library
Addictions are highly heritable disorders, with heritability estimates ranging from 39% to
72%. Multiple studies suggest a link between paternal drug abuse and addiction in their …

Environmental, genetic and epigenetic contributions to cocaine addiction

RC Pierce, B Fant, SE Swinford-Jackson… - …, 2018 - nature.com
Decades of research on cocaine has produced volumes of data that have answered many
important questions about the nature of this highly addictive drug. Sadly, none of this …

[HTML][HTML] Multigenerational epigenetic inheritance: One step forward, two generations back

JJ Tuscher, JJ Day - Neurobiology of Disease, 2019 - Elsevier
Modifications to DNA and histone proteins serve a critical regulatory role in the developing
and adult brain, and over a decade of research has established the importance of these …

Ejaculate-mediated paternal effects: evidence, mechanisms and evolutionary implications

JP Evans, AJ Wilson, A Pilastro… - …, 2019 - rep.bioscientifica.com
Despite serving the primary objective of ensuring that at least one sperm cell reaches and
fertilises an ovum, the male ejaculate (ie spermatozoa and seminal fluid) is a …

Sperm RNA payload: implications for intergenerational epigenetic inheritance

S Liu, U Sharma - International journal of molecular sciences, 2023 - mdpi.com
There is mounting evidence that ancestral life experiences and environment can influence
phenotypes in descendants. The parental environment regulates offspring phenotypes …