Fibrosis is characterized by the excessive extracellular matrix deposition due to
dysregulated wound and connective tissue repair response. Multiple organs can develop …

Chronic kidney disease (CKD) is a chronic renal dysfunction syndrome that is characterized
by nephron loss, inflammation, myofibroblasts activation, and extracellular matrix (ECM) …

Transforming growth factor-β (TGF-β) is the primary factor that drives fibrosis in most, if not
all, forms of chronic kidney disease (CKD). Inhibition of the TGF-β isoform, TGF-β1, or its …

Transforming growth factor β (TGF-β) and related growth factors are secreted pleiotropic
factors that play critical roles in embryogenesis and adult tissue homeostasis by regulating …

Lysine acetylation is a conserved protein post-translational modification that links acetyl-
coenzyme A metabolism and cellular signalling. Recent advances in the identification and …

Inflammation and fibrosis are two pathological features of chronic kidney disease (CKD).
Transforming growth factor-β (TGF-β) has been long considered as a key mediator of renal …

Renal fibrosis is characterized by excessive deposition of extracellular matrix (ECM) that
disrupts and replaces functional parenchyma, which leads to organ failure. It is known as the …

Transforming growth factor-β (TGF-β) signaling is essential in embryo development and
maintaining normal homeostasis. Extensive evidence shows that TGF-β activation acts on …

Several mechanisms underlying tumor progression have remained elusive, particularly in
relation to transforming growth factor beta (TGF-β). Although TGF-β initially inhibits epithelial …

Transforming growth factor-beta (TGFβ) is a key regulator of cell fate during embryogenesis
and has also emerged as a potent driver of the epithelial-mesenchymal transition during …