[HTML][HTML] Cell signaling by receptor tyrosine kinases
J Schlessinger - Cell, 2000 - cell.com
(Hunter, 1998). RTKs play an important role in the control 1998; Jiang and Hunter, 1999).
Receptor dimerization is of most fundamental cellular processes including the further …
Receptor dimerization is of most fundamental cellular processes including the further …
Rab proteins as membrane organizers
Cellular organelles in the exocytic and endocytic pathways have a distinctive spatial
distribution and communicate through an elaborate system of vesiculo-tubular transport …
distribution and communicate through an elaborate system of vesiculo-tubular transport …
Spatiotemporal control of endocytosis by phosphatidylinositol-3, 4-bisphosphate
Y Posor, M Eichhorn-Gruenig, D Puchkov… - Nature, 2013 - nature.com
Phosphoinositides serve crucial roles in cell physiology, ranging from cell signalling to
membrane traffic,. Among the seven eukaryotic phosphoinositides the best studied species …
membrane traffic,. Among the seven eukaryotic phosphoinositides the best studied species …
Cellular survival: a play in three Akts
The programmed cell death that occurs as part of normal mammalian development was first
observed nearly a century ago (Collin 1906). It has since been established that …
observed nearly a century ago (Collin 1906). It has since been established that …
[HTML][HTML] Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase/akt pathway
The S/T-protein kinases activated by phosphoinositide 3-kinase (PI3K) regulate a myriad of
cellular processes. Here, we show that an approach using a combination of biochemistry …
cellular processes. Here, we show that an approach using a combination of biochemistry …
PI3K-Akt pathway: its functions and alterations in human cancer
M Osaki, M Oshimura, H Ito - Apoptosis, 2004 - Springer
Abstract Phosphatidylinositol-3-kinase (PI3K) is a lipid kinase and generates
phosphatidylinositol-3, 4, 5-trisphosphate (PI (3, 4, 5) P3). PI (3, 4, 5) P3 is a second …
phosphatidylinositol-3, 4, 5-trisphosphate (PI (3, 4, 5) P3). PI (3, 4, 5) P3 is a second …
Epidermal growth factor receptor: mechanisms of activation and signalling
RN Jorissen, F Walker, N Pouliot, TPJ Garrett… - The EGF receptor …, 2003 - Elsevier
Publisher Summary This chapter discusses the structure and function of the epidermal
growth factor (EGF) receptor (EGFR), from ligand binding to the initiation of intracellular …
growth factor (EGF) receptor (EGFR), from ligand binding to the initiation of intracellular …
[HTML][HTML] Interaction between Wnt/β-catenin and RAS-ERK pathways and an anti-cancer strategy via degradations of β-catenin and RAS by targeting the Wnt/β-catenin …
Aberrant activation of the Wnt/β-catenin and RAS-extracellular signal-regulated kinase
(ERK) pathways play important roles in the tumorigenesis of many different types of cancer …
(ERK) pathways play important roles in the tumorigenesis of many different types of cancer …
PI3K/Akt and apoptosis: size matters
TF Franke, CP Hornik, L Segev, GA Shostak… - Oncogene, 2003 - nature.com
Recent research has examined Akt and Akt-related serine–threonine kinases in signaling
cascades that regulate cell survival and are important in the pathogenesis of degenerative …
cascades that regulate cell survival and are important in the pathogenesis of degenerative …
Target of rapamycin (TOR): an integrator of nutrient and growth factor signals and coordinator of cell growth and cell cycle progression
DC Fingar, J Blenis - Oncogene, 2004 - nature.com
Cell growth (an increase in cell mass and size through macromolecular biosynthesis) and
cell cycle progression are generally tightly coupled, allowing cells to proliferate continuously …
cell cycle progression are generally tightly coupled, allowing cells to proliferate continuously …