Cancer-associated fibroblasts (CAFs) are central players in the microenvironment of solid
tumors, affecting cancer progression and metastasis. CAFs have diverse phenotypes …

Activated fibroblasts in tumors, or cancer-associated fibroblasts (CAFs), have become a
popular research area over the past decade. As important players in many aspects of tumor …

Efforts to develop anti-cancer therapies have largely focused on targeting the epithelial
compartment, despite the presence of non-neoplastic stromal components that substantially …

Exosomes are a subpopulation of the tumour microenvironment (TME) that transmit various
biological molecules to promote intercellular communication. Exosomes are derived from …

Ovarian cancer is the leading cause of gynecological malignancy–related deaths, due to its
widespread intraperitoneal metastases and acquired chemoresistance. Mesothelial cells are …

Pancreatic ductal adenocarcinoma (PDAC) is a leading cause of cancer-related morbidity
and mortality in the western world, with limited therapeutic strategies and dismal long-term …

The tumor microenvironment (TME) is comprised of many different cell populations, such as
cancer-associated fibroblasts and various infiltrating immune cells, and non-cell …

The peritoneum is an extensive serous organ with both epithelial and mesenchymal features
and a variety of functions. Diseases such as inflammatory peritonitis and peritoneal …

Peritoneal metastasis is a primary metastatic route for gastric cancers, and the mechanisms
underlying this process are still unclear. Peritoneal mesothelial cells (PMCs) undergo …

Various types of tumors, particularly those originating from the ovary and gastrointestinal
tract, display a strong predilection for the peritoneal cavity as the site of metastasis. The …