Mesothelial-to-mesenchymal transition and exosomes in peritoneal metastasis of ovarian cancer

L Pascual-Antón, B Cardeñes… - International journal of …, 2021 - mdpi.com
Most patients with ovarian cancer (OvCA) present peritoneal disseminated disease at the
time of diagnosis. During peritoneal metastasis, cancer cells detach from the primary tumor …

Cancer associated fibroblasts: naughty neighbors that drive ovarian cancer progression

S Dasari, Y Fang, AK Mitra - Cancers, 2018 - mdpi.com
Ovarian cancer is the most lethal gynecologic malignancy, and patient prognosis has not
improved significantly over the last several decades. In order to improve therapeutic …

TGFβ signaling networks in ovarian cancer progression and plasticity

A Kumari, Z Shonibare, M Monavarian… - Clinical & Experimental …, 2021 - Springer
Epithelial ovarian cancer (EOC) is a leading cause of cancer-related death in women. Late-
stage diagnosis with significant tumor burden, accompanied by recurrence and …

The molecular biology of peritoneal metastatic disease

S Bootsma, MF Bijlsma, L Vermeulen - EMBO molecular medicine, 2023 - embopress.org
Peritoneal metastases are a common form of tumor cell dissemination in gastrointestinal
malignancies. Peritoneal metastatic disease (PMD) is associated with severe morbidity and …

The transcoelomic ecosystem and epithelial ovarian cancer dissemination

SJ Ritch, CM Telleria - Frontiers in Endocrinology, 2022 - frontiersin.org
Epithelial ovarian cancer (EOC) is considered the deadliest gynecological disease and is
normally diagnosed at late stages, at which point metastasis has already occurred …

Albumin-based cancer therapeutics for intraperitoneal drug delivery: a review

L Van de Sande, S Cosyns, W Willaert, W Ceelen - Drug Delivery, 2020 - Taylor & Francis
Albumin is a remarkable carrier protein with multiple cellular receptor and ligand binding
sites, which are able to bind and transport numerous endogenous and exogenous …

Targeting the immune microenvironment in the treatment of head and neck squamous cell carcinoma

HC Wang, LP Chan, SF Cho - Frontiers in Oncology, 2019 - frontiersin.org
Head and neck squamous cell carcinoma (HNSCC) is a highly aggressive solid tumor, with
a 5-year mortality rate of~ 50%. The development of immunotherapies has improved the …

[HTML][HTML] BGN/FAP/STAT3 positive feedback loop mediated mutual interaction between tumor cells and mesothelial cells contributes to peritoneal metastasis of gastric …

H Wu, Z Xiang, G Huang, Q He, J Song… - … journal of biological …, 2023 - ncbi.nlm.nih.gov
Peritoneal metastasis (PM) is most frequent in gastric cancer (GC) and cancer-associated
fibroblasts (CAFs) play a critical role in this process. However, the concrete mechanism of …

Peritoneal restoration by repurposing vitamin D inhibits ovarian cancer dissemination via blockade of the TGF-β1/thrombospondin-1 axis

K Kitami, M Yoshihara, S Tamauchi, M Sugiyama… - Matrix Biology, 2022 - Elsevier
Ovarian cancer (OvCa), a lethal gynecological malignancy, disseminates to the peritoneum.
Mesothelial cells (MCs) act as barriers in the abdominal cavity, preventing the adhesion of …

Gastric cancer‐derived exosomes promote peritoneal metastasis by destroying the mesothelial barrier

G Deng, J Qu, Y Zhang, X Che, Y Cheng, Y Fan… - Febs …, 2017 - Wiley Online Library
An intact mesothelium serves as a protective barrier to inhibit peritoneal carcinomatosis.
Cancer‐derived exosomes can mediate directional tumor metastasis; however, little is …