Mesothelial to mesenchyme transition as a major developmental and pathological player in trunk organs and their cavities

T Koopmans, Y Rinkevich - Communications Biology, 2018 - nature.com
The internal organs embedded in the cavities are lined by an epithelial monolayer termed
the mesothelium. The mesothelium is increasingly implicated in driving various internal …

The role of cancer-associated mesothelial cells in the progression and therapy of ovarian cancer

A Zheng, Y Wei, Y Zhao, T Zhang, X Ma - Frontiers in immunology, 2022 - frontiersin.org
Ovarian cancer is currently one of the most common malignant tumors in females with poor
survival rates around the world, killing about 200,000 women each year. Although great …

Role of tumor microenvironment in the pathobiology of ovarian cancer: Insights and therapeutic opportunities

A Ghoneum, H Afify, Z Salih, M Kelly, N Said - Cancer medicine, 2018 - Wiley Online Library
Ovarian cancer is the fifth most common cancer affecting women and at present, stands as
the most lethal gynecologic malignancy. The poor disease outcome is due to the nonspecific …

LncRNA SPOCD1-AS from ovarian cancer extracellular vesicles remodels mesothelial cells to promote peritoneal metastasis via interacting with G3BP1

C Wang, J Wang, X Shen, M Li, Y Yue, X Cheng… - Journal of Experimental …, 2021 - Springer
Background Metastasis is the key cause of death in ovarian cancer patients. To figure out
the biological nature of cancer metastasis is essential for developing effective targeted …

Role of Cancer-Associated fibroblast in the pathogenesis of ovarian Cancer: Focus on the latest therapeutic approaches

H Ding, J Zhang, F Zhang, Y Xu, Y Yu, W Liang… - International …, 2022 - Elsevier
Ovarian cancer (OC) is the seventh most common malignancy in women globally. This type
of cancer can occur at any age, but it is more frequent in women over 50 and is usually …

PAI-1 secreted from metastatic ovarian cancer cells triggers the tumor-promoting role of the mesothelium in a feedback loop to accelerate peritoneal dissemination

Y Peng, H Kajiyama, H Yuan, K Nakamura… - Cancer Letters, 2019 - Elsevier
The mesothelium, covered by a continuous monolayer of mesothelial cells, is the first
protective barrier against metastatic ovarian cancer. However, mesothelial cells release …

Bête noire of chemotherapy and targeted therapy: CAF-mediated resistance

P De, J Aske, R Sulaiman, N Dey - Cancers, 2022 - mdpi.com
Simple Summary Tumor cells struggle to survive following treatment. The struggle ends in
either of two ways. The drug combination used for the treatment blocks the proliferation of …

The metastatic phenotype shift toward myofibroblast of adipose-derived mesenchymal stem cells promotes ovarian cancer progression

H Tang, Y Chu, Z Huang, J Cai, Z Wang - Carcinogenesis, 2020 - academic.oup.com
Ovarian cancer metastasizes to organs in the abdominal cavity, such as the omentum that is
a rich source of adipose-derived mesenchymal stem cells (ADSCs). In present, ADSCs have …

Mesothelial cell HIF1α expression is metabolically downregulated by metformin to prevent oncogenic tumor-stromal crosstalk

PC Hart, HA Kenny, N Grassl, KM Watters, LM Litchfield… - Cell reports, 2019 - cell.com
The tumor microenvironment (TME) plays a pivotal role in cancer progression, and, in
ovarian cancer (OvCa), the primary TME is the omentum. Here, we show that the diabetes …

Extracellular vesicles promote the formation of pre-metastasis niche in gastric cancer

D Tang, S Liu, H Shen, G Deng, S Zeng - Frontiers in Immunology, 2022 - frontiersin.org
Globally, gastric cancer (GC) ranks fourth in the incidence of malignant tumors. The early
clinical manifestations of GC lack specificity. Most patients are already at an advanced stage …