Acute nociceptive pain is a key defence system that enables the detection of danger signals
that threaten homeostasis and survival. However, chronic pain (such as the neuropathic …

Reciprocal signalling between immunocompetent cells in the central nervous system (CNS)
has emerged as a key phenomenon underpinning pathological and chronic pain …

Migraine and neuropathic pain (NP) are both painful, disabling, chronic conditions which
exhibit some symptom similarities and are thus considered to share a common etiology. The …

Inflammation is the process by which an organism responds to tissue injury involving both
immune cell recruitment and mediator release. Diverse causes of neuropathic pain are …

Persistent pain is a sequela of several neurological conditions with a primary immune basis,
such as Guillain-Barré syndrome and multiple sclerosis. Additionally, diverse forms of injury …

Idiopathic Parkinson's disease (PD) is a neurodegenerative disorder associated with
akinesia, tremor and rigidity. While the characteristic Lewy body pathology targets …

Injuries to the peripheral nerves result in partial or total loss of motor, sensory and autonomic
functions conveyed by the lesioned nerves to the denervated segments of the body, due to …

Neuroinflammatory glial response may contribute to degenerative processes in Parkinson's
disease (PD). To investigate changes in microglial activity associated with changes in the …

Neuroinflammation is implicated in the pathophysiology of a growing number of human
disorders, including multiple sclerosis, chronic pain, traumatic brain injury, and amyotrophic …

Glial activation participates in the mediation of pain including neuropathic pain, due to
release of neuroexcitatory, proinflammatory products. Glial activation is now known to occur …