The remarkable evolutionary plasticity of coronaviruses by mutation and recombination: insights for the COVID-19 pandemic and the future evolutionary paths of …
GD Amoutzias, M Nikolaidis, E Tryfonopoulou… - Viruses, 2022 - mdpi.com
Coronaviruses (CoVs) constitute a large and diverse subfamily of positive-sense single-
stranded RNA viruses. They are found in many mammals and birds and have great …
stranded RNA viruses. They are found in many mammals and birds and have great …
[HTML][HTML] The role of SARS-CoV-2 accessory proteins in immune evasion
Many questions on the SARS-CoV-2 pathogenesis remain to answer. The SARS-CoV-2
genome encodes some accessory proteins that are essential for infection. Notably …
genome encodes some accessory proteins that are essential for infection. Notably …
Structural and non-structural proteins in SARS-CoV-2: potential aspects to COVID-19 treatment or prevention of progression of related diseases
S Kakavandi, I Zare, M VaezJalali, M Dadashi… - Cell Communication and …, 2023 - Springer
Abstract Coronavirus disease 2019 (COVID-19) is caused by a new member of the
Coronaviridae family known as severe acute respiratory syndrome coronavirus 2 (SARS …
Coronaviridae family known as severe acute respiratory syndrome coronavirus 2 (SARS …
[HTML][HTML] SARS-CoV-2 ORF3a sensitizes cells to ferroptosis via Keap1-NRF2 axis
L Liu, J Du, S Yang, B Zheng, J Shen, J Huang, L Cao… - Redox Biology, 2023 - Elsevier
Viral infection-induced cell death has long been considered as a double-edged sword in the
inhibition or exacerbation of viral infections. Patients with severe Coronavirus Disease 2019 …
inhibition or exacerbation of viral infections. Patients with severe Coronavirus Disease 2019 …
SARS-CoV-2 ORF8: a rapidly evolving immune and viral modulator in COVID-19
A Arduini, F Laprise, C Liang - Viruses, 2023 - mdpi.com
The COVID-19 pandemic has resulted in upwards of 6.8 million deaths over the past three
years, and the frequent emergence of variants continues to strain global health. Although …
years, and the frequent emergence of variants continues to strain global health. Although …
Infection of primary nasal epithelial cells differentiates among lethal and seasonal human coronaviruses
CJ Otter, A Fausto, LH Tan, AS Khosla… - Proceedings of the …, 2023 - National Acad Sciences
The nasal epithelium is the initial entry portal and primary barrier to infection by all human
coronaviruses (HCoVs). We utilize primary human nasal epithelial cells grown at air–liquid …
coronaviruses (HCoVs). We utilize primary human nasal epithelial cells grown at air–liquid …
Severe acute respiratory syndrome coronaviruses contributing to mitochondrial dysfunction: Implications for post-COVID complications
Mitochondria play a central role in oxidative phosphorylation (OXPHOS), bioenergetics
linked with ATP production, fatty acids biosynthesis, calcium signaling, cell cycle regulation …
linked with ATP production, fatty acids biosynthesis, calcium signaling, cell cycle regulation …
SARS-CoV-2 ORF8 accessory protein is a virulence factor
M Bello-Perez, J Hurtado-Tamayo, AZ Mykytyn… - Mbio, 2023 - Am Soc Microbiol
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) encodes six accessory
proteins (3a, 6, 7a, 7b, 8, and 9b) for which limited information is available on their role in …
proteins (3a, 6, 7a, 7b, 8, and 9b) for which limited information is available on their role in …
[HTML][HTML] Contribution to pathogenesis of accessory proteins of deadly human coronaviruses
J Hurtado-Tamayo, R Requena-Platek… - Frontiers in Cellular …, 2023 - frontiersin.org
Coronaviruses (CoVs) are enveloped and positive-stranded RNA viruses with a large
genome (∼ 30kb). CoVs include essential genes, such as the replicase and four genes …
genome (∼ 30kb). CoVs include essential genes, such as the replicase and four genes …
Network for network concept offers new insights into host-SARS-CoV-2 protein interactions and potential novel targets for developing antiviral drugs
Abstract SARS-CoV-2, the causal agent of COVID-19, is primarily a pulmonary virus that can
directly or indirectly infect several organs. Despite many studies carried out during the …
directly or indirectly infect several organs. Despite many studies carried out during the …