Low bone mineral density (BMD) is used as a parameter of osteoporosis. Genome-wide
association studies of BMD have hitherto focused on BMD as a quantitative trait, yielding …

Osteoporosis is defined as low bone mineral density associated with skeletal fractures
secondary to minimal or no trauma, most often involving the spine, the hip, and the forearm …

Osteoporotic fracture is a major cause of morbidity and mortality worldwide. Low bone
mineral density (BMD) is a major predisposing factor to fracture and is known to be highly …

In an extended genome-wide association study of bone mineral density among 6,865
Icelanders and a follow-up in 8,510 subjects of European descent, we identified four new …

Osteoporosis is a devastating disease with an essential genetic component. GWAS have
discovered genetic signals robustly associated with bone mineral density (BMD), but not the …

Kidney stone disease is a common condition. To search for sequence variants conferring
risk of kidney stones, we conducted a genome-wide association study in 3,773 cases and …

Background: Osteoporosis is a highly heritable trait. Many candidate genes have been
proposed as being involved in regulating bone mineral density (BMD). Few of these findings …

Recent genome-wide (GW) scans have identified several independent loci affecting human
stature, but their contribution through the different skeletal components of height is still …

OBJECTIVE—Metformin, an oral glucose-lowering drug, is taken up in hepatocytes by the
organic cation transporter (OCT) 1 and in renal epithelium by OCT2. In these cells, the …

Objective To identify novel genes involved in osteoarthritis (OA), by means of a genome‐
wide association study. Methods We tested 500,510 single‐nucleotide polymorphisms …