Objective Lumbar disc degeneration (LDD) is an important cause of low back pain, which is
a common and costly problem. LDD is characterised by disc space narrowing and …

Aims/hypothesis In this study we aimed to replicate the previously reported association
between the glycaemic response to metformin and the SNP rs11212617 at a locus that …

Most previous genetic epidemiology studies within the field of osteoporosis have focused on
the genetics of the complex trait areal bone mineral density (aBMD), not being able to …

A family history of hip fracture carries a twofold increased risk of fracture among
descendants. Genetic factors indeed play a major role in the determination of bone mineral …

Background Osteoporosis is a complex disease with a strong genetic contribution. A recently
published genome-wide association study (GWAS) for estimated bone mineral density …

Reduced bone mineral density (BMD; ie, Z‐score≤− 2.0) occurring at a young age (ie,
premenopausal women and men< 50 years) in the absence of secondary osteoporosis is …

Bone mineral density is known to be a heritable, polygenic trait whereas genetic variants
contributing to lean mass variation remain largely unknown. We estimated the shared SNP …

Abstract Purpose of Review The purpose of this review is to summarize the different roles of
the transcription factor SP7 in regulating bone formation and remodeling, discuss current …

BACKGROUND: The etiology of cardiovascular disease (CVD) is multifactorial. Efforts to
identify genes influencing CVD risk have met with limited success to date, likely because of …

High melanocytic nevus count is a strong predictor of melanoma risk. A GWAS of nevus
count in Australian adolescent twins identified an association of nevus count with the …