Precise control of gene expression is fundamental to cell function and development.
Although ultimately gene expression relies on DNA-binding transcription factors to guide the …

Cells differentiate and progress through development guided by a dynamic chromatin
landscape that mediates gene expression programmes. During development, mammalian …

Polycomb group (PcG) proteins are crucial chromatin regulators that maintain repression of
lineage-inappropriate genes and are therefore required for stable cell fate. Recent advances …

Silencing of a subset of germline genes is dependent upon DNA methylation (DNAme) post-
implantation. However, these genes are generally hypomethylated in the blastocyst …

Background Early embryonic developmental programs are guided by the coordinated
interplay between maternally inherited and zygotically manufactured RNAs and proteins …

Polycomb repressive complexes 1 and 2 (PRC1 and 2) are required for heritable repression
of developmental genes. The cis-and trans-acting factors that contribute to epigenetic …

Marked epigenetic reprogramming is essential to convert terminally differentiated gametes
to totipotent embryos. It remains puzzling why postfertilization global DNA reprogramming …

During the emergence and radiation of complex multicellular eukaryotes from unicellular
ancestors, transcriptional systems evolved by becoming more complex to provide the basis …

The histone variant H2A. Z is central to early embryonic development, determining
transcriptional competency through chromatin regulation of gene promoters and enhancers …

Epigenetic modifications undergo drastic erasure and reestablishment after fertilization. This
reprogramming is required for proper embryonic development and cell differentiation. In …