Reactive oxygen species scavenging nanomedicine for the treatment of ischemic heart disease

Z Zhang, R Dalan, Z Hu, JW Wang… - Advanced …, 2022 - Wiley Online Library
Ischemic heart disease (IHD) is the leading cause of disability and mortality worldwide.
Reactive oxygen species (ROS) have been shown to play key roles in the progression of …

Targeting vascular (endothelial) dysfunction

A Daiber, S Steven, A Weber… - British journal of …, 2017 - Wiley Online Library
Cardiovascular diseases are major contributors to global deaths and disability‐adjusted life
years, with hypertension a significant risk factor for all causes of death. The endothelium that …

Recent advances in PEG–PLA block copolymer nanoparticles

RZ Xiao, ZW Zeng, GL Zhou, JJ Wang… - International journal …, 2010 - Taylor & Francis
Due to their small particle size and large and modifiable surface, nanoparticles have unique
advantages compared with other drug carriers. As a research focus in recent years …

Targeting drug delivery in the vascular system: Focus on endothelium

PM Glassman, JW Myerson, LT Ferguson… - Advanced drug delivery …, 2020 - Elsevier
The bloodstream is the main transporting pathway for drug delivery systems (DDS) from the
site of administration to the intended site of action. In many cases, components of the …

Role of glutathione peroxidases and peroxiredoxins in free radical-induced pathologies

MG Shaparov, SV Gudkov, VZ Lankin… - Biochemistry (Moscow …, 2021 - Springer
In this review, we discuss the pathogenesis of some socially significant diseases associated
with the development of oxidative stress, such as atherosclerosis, diabetes, and radiation …

The role of particle geometry and mechanics in the biological domain

JP Best, Y Yan, F Caruso - Advanced healthcare materials, 2012 - Wiley Online Library
Nanostructured particulate materials are expected to revolutionize diagnostics and the
delivery of therapeutics for healthcare. To date, chemistry‐derived solutions have been the …

Nanocarriers for vascular delivery of antioxidants

E Hood, E Simone, P Wattamwar, T Dziubla… - …, 2011 - Taylor & Francis
Antioxidant enzymes (AOEs) catalase and superoxide dismutase (SOD) detoxify harmful
reactive oxygen species, but the therapeutic utility of AOEs is hindered by inadequate …

Endothelial targeting of antibody-decorated polymeric filomicelles

VV Shuvaev, MA Ilies, E Simone, S Zaitsev, Y Kim… - ACS …, 2011 - ACS Publications
The endothelial lining of the lumen of blood vessels is a key therapeutic target for many
human diseases. Polymeric filomicelles that self-assemble from polyethylene oxide (PEO) …

Advanced drug delivery systems for antithrombotic agents

CF Greineder, MD Howard… - Blood, The Journal …, 2013 - ashpublications.org
Despite continued achievements in antithrombotic pharmacotherapy, difficulties remain in
managing patients at high risk for both thrombosis and hemorrhage. Utility of antithrombotic …

Cross-linked antioxidant nanozymes for improved delivery to CNS

NL Klyachko, DS Manickam, AM Brynskikh… - … , biology and medicine, 2012 - Elsevier
Formulations of antioxidant enzymes, superoxide dismutase 1 (SOD1, also known as Cu/Zn
SOD) and catalase were prepared by electrostatic coupling of enzymes with cationic block …