Anxiety is the most common mental health problem worldwide. Epidemiological studies
show that sleep disturbances, particularly insomnia, affect∼ 50% of individuals with anxiety …

Pharmaceuticals and personal care products (PPCPs) are found in wastewater, and thus,
the environment. In this study, current knowledge about the occurrence and fate of PPCPs in …

Caffeine is consumed by over 80% of US adults. This review examines the effects caffeine
has on cognitive and physical function, since most real-world activities require complex …

Processing urban waste is becoming a major challenge, with the current state and
forecasted increase in urbanisation. Finding novel approaches to reduce and recycle this …

Caffeine ranks as one of the top most commonly consumed dietary ingredients throughout
the world. It is naturally found in coffee beans, cacao beans, kola nuts, guarana berries, and …

Coffee is a complex mixture of chemicals that provides significant amounts of chlorogenic
acid and caffeine. Unfiltered coffee is a significant source of cafestol and kahweol, which are …

Caffeine (1, 3, 7-trimethylxanthine) is the most consumed psychoactive substance in the
world, acting by means of antagonism to adenosine receptors, mainly A1 and A2A. Coffee is …

Drugs, their targets and the nature and number of drug targets | Nature Reviews Drug Discovery
Skip to main content Thank you for visiting nature.com. You are using a browser version with …

Caffeine is being increasingly used in cosmetics due to its high biological activity and ability
to penetrate the skin barrier. This alkaloid is frequently used as a hydrophilic model …

The locus coeruleus (LC), the major noradrenergic nucleus of the brain, gives rise to fibres
innervating most structures of the neuraxis. Recent advances in neuroscience have helped …