Emodin is a natural occurring anthraquinone derivative isolated from roots and barks of
numerous plants, molds, and lichens. It is found to be an active ingredient in different …

Currently, hundreds of herbal products with potential hepatotoxicity were available in the
literature. A comprehensive summary and analysis focused on these potential hepatotoxic …

Abstract Chinese herb Rhubarb (Dahuang), one of the most widely used traditional Chinese
medicine in clinical application for over a thousand years and known as the “General (Jiang …

Herbal and dietary supplements (HDS)-induced liver injury has been a great concern all
over the world. Polygonum multiflorum Thunb., a well-known Chinese herbal medicine, is …

Liver injury could be caused by a variety of causes, including alcohol, drug poisoning,
autoimmune overreaction, etc. In the period of liver injury, hepatic stellate cells (HSCs) will …

Gender is an important risk factor for adverse drug reactions. Women report significantly
more adverse drug reactions than men. There is a growing consensus that gender …

Rhubarb palmatum L., Polygonum multijiorum Thunb., and Polygonum cuspidatum Sieb. Et
Zucc. are traditional Chinese medicines that have been used for thousands of years. They …

UDP-glucuronosyltransferases (UGTs) are involved in phase II conjugation reactions of
xenobiotics and differences in their isoform activities result in interindividual kinetic …

Emodin is the main pharmacodynamic components of rhubarb, with significant
pharmacological effects and clinical efficacy. Emodin has a variety of therapy effects, such …

Herbal medicine is widely used in Asia as well as the west. Hepatotoxicity is one of the most
severe side effects of herbal medicine which is an increasing concern around the world …