Targeting noncoding RNAs in disease

BD Adams, C Parsons, L Walker… - The Journal of …, 2017 - Am Soc Clin Investig
Many RNA species have been identified as important players in the development of chronic
diseases, including cancer. Over the past decade, numerous studies have highlighted how …

LncRNAs as potential diagnostic and prognostic biomarkers in gastric cancer: a novel approach to personalized medicine

S Fattahi, M Kosari‐Monfared… - Journal of cellular …, 2020 - Wiley Online Library
Gastric cancer is the third leading cause of cancer death with 5‐year survival rate of about
30–35%. Since early detection is associated with decreased mortality, identification of novel …

Long non‑coding RNA GAS5 in human cancer

X Yang, Z Xie, X Lei, R Gan - Oncology letters, 2020 - spandidos-publications.com
Long non‑coding RNAs (lncRNAs) constitute a group of> 200‑nucleotide ncRNA molecules.
lncRNAs regulate several cell functions, such as proliferation, apoptosis, invasion and …

Long non-coding RNAs as the critical regulators of doxorubicin resistance in tumor cells

G Khalili-Tanha, M Moghbeli - Cellular & Molecular Biology Letters, 2021 - Springer
Resistance against conventional chemotherapeutic agents is one of the main reasons for
tumor relapse and poor clinical outcomes in cancer patients. Various mechanisms are …

SDLDA: lncRNA-disease association prediction based on singular value decomposition and deep learning

M Zeng, C Lu, F Zhang, Y Li, FX Wu, Y Li, M Li - Methods, 2020 - Elsevier
In recent years, accumulating studies have shown that long non-coding RNAs (lncRNAs) not
only play an important role in the regulation of various biological processes but also are the …

Regulatory roles of long noncoding RNAs implicated in cancer hallmarks

J Wang, X Zhang, W Chen, X Hu, J Li… - International journal of …, 2020 - Wiley Online Library
Cancer cells acquire numerous biological properties (designated “cancer hallmarks”), such
as cell survival and energy metabolism, that facilitate tumor growth and metastatic …

Long non-coding RNA signature in gastric cancer

S Ghafouri-Fard, M Taheri - Experimental and Molecular Pathology, 2020 - Elsevier
Gastric cancer as a common human malignancy has been associated with aberrant
expressions of several coding and non-coding genes. Long non-coding RNAs (lncRNAs) as …

The role of long non-coding RNA GAS5 in cancers

J Ji, X Dai, SCJ Yeung, X He - Cancer management and research, 2019 - Taylor & Francis
Long non-coding RNAs (lncRNAs) have shown potential as a biomarker in the diagnosis
and prognosis in multiple cancers. LncRNAs are dysregulated in various cancers, playing …

The cross-talk between LncRNAs and JAK-STAT signaling pathway in cancer

A Hjazi, RF Obaid, SS Ali, B Abdullaev… - … -Research and Practice, 2023 - Elsevier
Long non-coding RNAs (lncRNAs) are non-coding RNAs that were transcribed from the
human genome and have become important regulators in a number of cellular activities …

Long noncoding RNA GAS5 regulates the proliferation, migration, and invasion of glioma cells by negatively regulating miR‐18a‐5p

Q Liu, W Yu, S Zhu, K Cheng, H Xu, Y Lv… - Journal of cellular …, 2019 - Wiley Online Library
Intention Long noncoding RNAs, transcribed from a recently discovered class of noncoding
genes, may play a critical role in regulating cellular processes, such as cell proliferation and …