Recent advances in functionalized quinoline scaffolds and hybrids—Exceptional pharmacophore in therapeutic medicine

OF Elebiju, OO Ajani, GO Oduselu… - Frontiers in …, 2023 - frontiersin.org
Quinoline is one of the most common nitrogen-containing heterocycles owing to its
fascinating pharmacological properties and synthetic value in organic and pharmaceutical …

Indole-based compounds as potential drug candidates for SARS-CoV-2

AS Girgis, SS Panda, BM Kariuki, MS Bekheit… - Molecules, 2023 - mdpi.com
The COVID-19 pandemic has posed a significant threat to society in recent times,
endangering human health, life, and economic well-being. The disease quickly spreads due …

Mechanistic action of linalyl acetate: Acyclic monoterpene isolated from bitter orange leaf as anti-inflammatory, analgesic, antipyretic agent: Role of TNF-α, IL1β, PGE2 …

A Alqahtani, MF Abdelhameed, R Abdou… - Industrial Crops and …, 2023 - Elsevier
The intervention of inflammation disorders with conventional synthetic drugs has several
hazards. Medicinal plants and their byproducts are beneficial in the treatment of …

Ibuprofen-loaded ZnO nanoparticle/polyacrylonitrile nanofibers for dual-stimulus sustained release of drugs

S Chao, Y Zhang, S Cheng, X Shao, S Liu… - ACS Applied Nano …, 2023 - ACS Publications
Based on the opportunities of ibuprofen administration innovation and challenges
associated with the construction of transdermal drug delivery systems using medicated …

Quinoline-based anti-MRSA agents: Current development, structure-activity relationships, and mechanisms

H Yao, L Cui, H Liu, X Li, L Shen, R Yang, S Qin… - Chinese Chemical …, 2024 - Elsevier
Methicillin-resistant Staphylococcus aureus (MRSA), the most common pathogen in hospital
and community environments, can cause serious and even fatal infections. The antibiotics …

Molecular hybridization of alkaloids using 1, 2, 3-triazole-based click chemistry

D Buchanan, AM Pham, SK Singh, SS Panda - Molecules, 2023 - mdpi.com
Alkaloids found in multiple species, known as 'driver species', are more likely to be included
in early-stage drug development due to their high biodiversity compared to rare alkaloids …

Synthesis of potential antiviral agents for SARS-CoV-2 using molecular hybridization approach

KA Wyman, AS Girgis, PS Surapaneni, JM Moore… - Molecules, 2022 - mdpi.com
We synthesized a set of small molecules using a molecular hybridization approach with
good yields. The antiviral properties of the synthesized conjugates against the SAR-CoV-2 …

A Review on Synthesis and Biological Applications of Quinoline Derivative as Fused Aromatic Compounds

M Mohasin, M Zafer Alam, Q Ullah… - Polycyclic Aromatic …, 2024 - Taylor & Francis
Quinoline is a N-containing heterocyclic organic compounds with significant biological
importance in pharmaceuticals field as well as natural products. They exhibit excellent …

Exploring Bioactive Potential of Streptomyces thinghirensis WAE1 from Wadi El-Natron, Egypt

ME Osman, AA Abo-Elnasr, ET Mohamed - Indian Journal of Microbiology, 2024 - Springer
This study aimed to investigate the bioactive metabolites produced by Streptomyces
thinghirensis WAE1, an actinomycete isolated from El-Hamara Lake in Egypt. The discovery …

[PDF][PDF] Annotated review on various biological activities of quinoline molecule

T Kaur, DD Bhandari - Biointerface Res. Appl. Chem, 2023 - biointerfaceresearch.com
Quinoline or Benzopyridine moiety remained an attraction among researchers in the 21st
century. Quinoline is a heterocyclic aromatic organic compound with the chemical formula …