End points for sickle cell disease clinical trials: patient-reported outcomes, pain, and the brain
AT Farrell, J Panepinto, CP Carroll, DS Darbari… - Blood …, 2019 - ashpublications.org
To address the global burden of sickle cell disease (SCD) and the need for novel therapies,
the American Society of Hematology partnered with the US Food and Drug Administration to …
the American Society of Hematology partnered with the US Food and Drug Administration to …
[HTML][HTML] AAPT diagnostic criteria for chronic sickle cell disease pain
C Dampier, TM Palermo, DS Darbari, K Hassell… - The Journal of …, 2017 - Elsevier
Pain in sickle cell disease (SCD) is associated with increased morbidity, mortality, and high
health care costs. Although episodic acute pain is the hallmark of this disorder, there is an …
health care costs. Although episodic acute pain is the hallmark of this disorder, there is an …
Pain in sickle cell disease: current and potential translational therapies
V Sagi, A Mittal, H Tran, K Gupta - Translational Research, 2021 - Elsevier
Pain is a major comorbidity of sickle cell disease (SCD). Patients with SCD may suffer from
both acute and chronic pain. Acute pain is caused by recurrent and unpredictable episodes …
both acute and chronic pain. Acute pain is caused by recurrent and unpredictable episodes …
[HTML][HTML] Current results and future research priorities in late effects after hematopoietic stem cell transplantation for children with sickle cell disease and thalassemia: a …
S Shenoy, E Angelucci, SD Arnold, KS Baker… - Biology of Blood and …, 2017 - Elsevier
Sustained donor engraftment after allogeneic hematopoietic cell transplantation (HCT)
converts to healthy donor hemoglobin synthesis and halts disease symptoms in patients with …
converts to healthy donor hemoglobin synthesis and halts disease symptoms in patients with …
Association between pain sensitization and disease activity in patients with rheumatoid arthritis: a cross‐sectional study
YC Lee, CO Bingham III, RR Edwards… - Arthritis care & …, 2018 - Wiley Online Library
Objective Pain sensitization may contribute to pain severity in rheumatoid arthritis (RA),
impacting disease activity assessment. We examined whether pain processing mechanisms …
impacting disease activity assessment. We examined whether pain processing mechanisms …
Cold exposure induces vaso-occlusion and pain in sickle mice that depend on complement activation
Vaso-occlusive pain episodes (VOE) cause severe pain in patients with sickle cell disease
(SCD). Vaso-occlusive events promote ischemia/reperfusion pathobiology that activates …
(SCD). Vaso-occlusive events promote ischemia/reperfusion pathobiology that activates …
[HTML][HTML] Daily opioid use fluctuates as a function of pain, catastrophizing, and affect in patients with sickle cell disease: an electronic daily diary analysis
Chronic opioid therapy is a common treatment regimen for patients with sickle cell disease
(SCD), a chronically painful recessive hemoglobinopathy. The collective risk profile of …
(SCD), a chronically painful recessive hemoglobinopathy. The collective risk profile of …
Neuropathic pain in individuals with sickle cell disease
D Sharma, AM Brandow - Neuroscience Letters, 2020 - Elsevier
Pain is the most frequently occurring complication of sickle cell disease (SCD) and the
leading cause of hospitalizations for affected individuals. Acute pain episodes are also an …
leading cause of hospitalizations for affected individuals. Acute pain episodes are also an …
[HTML][HTML] Sex differences in interleukin-6 responses over time following laboratory pain testing among patients with knee osteoarthritis
Epidemiological studies suggest that women are not only at a higher risk for developing
knee osteoarthritis (KOA), but also report greater symptom severity compared to men. One …
knee osteoarthritis (KOA), but also report greater symptom severity compared to men. One …
Mast cells induce blood brain barrier damage in SCD by causing endoplasmic reticulum stress in the endothelium
Endothelial dysfunction underlies the pathobiology of cerebrovascular disease. Mast cells
are located in close proximity to the vasculature, and vasoactive mediators released upon …
are located in close proximity to the vasculature, and vasoactive mediators released upon …